The international, prospective Glanzmann Thrombasthenia Registry : treatment and outcomes in surgical intervention
Copyright© Ferrata Storti Foundation..
Standard treatment for Glanzmann thrombasthenia, a severe inherited bleeding disorder, is platelet transfusion. Recombinant factor VIIa is reported to be effective in Glanzmann thrombasthenia with platelet antibodies and/or refractoriness to platelet transfusions. We aimed to evaluate recombinant factor VIIa effectiveness and safety for the treatment and prevention of surgical bleeding in patients, with or without platelet antibodies and/or refractoriness, using data from the Glanzmann Thrombasthenia Registry, an international, multicenter, observational, post-marketing study of rFVIIa. Between 2007 and 2011, 96 patients were treated for 206 surgical procedures (minor 169, major 37). History of platelet antibodies was present in 43 patients, refractoriness in 23, antibodies+refractoriness in 17, while 47 had no confirmed antibodies/refractoriness. Treatments analyzed included antifibrinolytics, recombinant factor VIIa, recombinant factor VIIa+antifibrinolytics, platelets±antifibrinolytics and recombinant factor VIIa+platelets±antifibrinolytics. The most frequent treatment for minor procedures was recombinant factor VIIa+antifibrinolytics (n=65), and for major procedures, recombinant factor VIIa+platelets±antifibrinolytics (n=13). In patients without antibodies/refractoriness, recombinant factor VIIa, either alone or with antifibrinolytics, and platelets±antifibrinolytics were rated 100% effective for minor and major procedures. The effectiveness of treatment for minor procedures in patients with antibodies and refractoriness was 88.9% for recombinant factor VIIa, 100% for recombinant factor VIIa+antifibrinolytics, 66.7% for platelets±antifibrinolytics and 100% for recombinant factor VIIa+platelets±antifibrinolytics. One of four adverse events reported for surgery was considered recombinant factor VIIa-treatment-related (non-fatal thromboembolic event in an adult female receiving recombinant factor VIIa+platelets+antifibrinolytics). For all patients, regardless of platelet antibody or refractoriness status, recombinant factor VIIa, administered with or without platelets (±antifibrinolytics), provided effective hemostasis with a low frequency of adverse events in surgical procedures in Glanzmann thrombasthenia patients. This trial was registered at clinicaltrials.gov identifier: 01476423.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:100 |
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| Enthalten in: |
Haematologica - 100(2015), 8 vom: 23. Aug., Seite 1038-44 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Poon, Man-Chiu [VerfasserIn] |
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| Links: |
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| Themen: |
AC71R787OV |
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| Anmerkungen: |
Date Completed 24.02.2016 Date Revised 31.03.2022 published: Print-Electronic ClinicalTrials.gov: NCT01476423 Citation Status MEDLINE |
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| doi: |
10.3324/haematol.2014.121384 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249279177 |
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| 100 | 1 | |a Poon, Man-Chiu |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The international, prospective Glanzmann Thrombasthenia Registry |b treatment and outcomes in surgical intervention |
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| 500 | |a Date Completed 24.02.2016 | ||
| 500 | |a Date Revised 31.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT01476423 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Ferrata Storti Foundation. | ||
| 520 | |a Standard treatment for Glanzmann thrombasthenia, a severe inherited bleeding disorder, is platelet transfusion. Recombinant factor VIIa is reported to be effective in Glanzmann thrombasthenia with platelet antibodies and/or refractoriness to platelet transfusions. We aimed to evaluate recombinant factor VIIa effectiveness and safety for the treatment and prevention of surgical bleeding in patients, with or without platelet antibodies and/or refractoriness, using data from the Glanzmann Thrombasthenia Registry, an international, multicenter, observational, post-marketing study of rFVIIa. Between 2007 and 2011, 96 patients were treated for 206 surgical procedures (minor 169, major 37). History of platelet antibodies was present in 43 patients, refractoriness in 23, antibodies+refractoriness in 17, while 47 had no confirmed antibodies/refractoriness. Treatments analyzed included antifibrinolytics, recombinant factor VIIa, recombinant factor VIIa+antifibrinolytics, platelets±antifibrinolytics and recombinant factor VIIa+platelets±antifibrinolytics. The most frequent treatment for minor procedures was recombinant factor VIIa+antifibrinolytics (n=65), and for major procedures, recombinant factor VIIa+platelets±antifibrinolytics (n=13). In patients without antibodies/refractoriness, recombinant factor VIIa, either alone or with antifibrinolytics, and platelets±antifibrinolytics were rated 100% effective for minor and major procedures. The effectiveness of treatment for minor procedures in patients with antibodies and refractoriness was 88.9% for recombinant factor VIIa, 100% for recombinant factor VIIa+antifibrinolytics, 66.7% for platelets±antifibrinolytics and 100% for recombinant factor VIIa+platelets±antifibrinolytics. One of four adverse events reported for surgery was considered recombinant factor VIIa-treatment-related (non-fatal thromboembolic event in an adult female receiving recombinant factor VIIa+platelets+antifibrinolytics). For all patients, regardless of platelet antibody or refractoriness status, recombinant factor VIIa, administered with or without platelets (±antifibrinolytics), provided effective hemostasis with a low frequency of adverse events in surgical procedures in Glanzmann thrombasthenia patients. This trial was registered at clinicaltrials.gov identifier: 01476423 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antifibrinolytic Agents |2 NLM | |
| 650 | 7 | |a Recombinant Proteins |2 NLM | |
| 650 | 7 | |a recombinant FVIIa |2 NLM | |
| 650 | 7 | |a AC71R787OV |2 NLM | |
| 650 | 7 | |a Factor VIIa |2 NLM | |
| 650 | 7 | |a EC 3.4.21.21 |2 NLM | |
| 700 | 1 | |a d'Oiron, Roseline |e verfasserin |4 aut | |
| 700 | 1 | |a Zotz, Rainer B |e verfasserin |4 aut | |
| 700 | 1 | |a Bindslev, Niels |e verfasserin |4 aut | |
| 700 | 1 | |a Di Minno, Matteo Nicola Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Di Minno, Giovanni |e verfasserin |4 aut | |
| 700 | 0 | |a Glanzmann Thrombasthenia Registry Investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Fathia, Grifi |e investigator |4 oth | |
| 700 | 1 | |a Nourredine, Sidi Mansour |e investigator |4 oth | |
| 700 | 1 | |a Naïma, Mesli |e investigator |4 oth | |
| 700 | 1 | |a Selma, Hamdi |e investigator |4 oth | |
| 700 | 1 | |a Meriem, Belhani |e investigator |4 oth | |
| 700 | 1 | |a Hadj, Touhami |e investigator |4 oth | |
| 700 | 1 | |a Heistinger, Max |e investigator |4 oth | |
| 700 | 1 | |a Kyrle, Paul Alexander |e investigator |4 oth | |
| 700 | 1 | |a Van Geet, Christel |e investigator |4 oth | |
| 700 | 1 | |a Labarque, Veerle |e investigator |4 oth | |
| 700 | 1 | |a Stoyanova, Angelina |e investigator |4 oth | |
| 700 | 1 | |a Sapunarova, Katya |e investigator |4 oth | |
| 700 | 1 | |a Oudot, Caroline |e investigator |4 oth | |
| 700 | 1 | |a d'Oiron, Roseline |e investigator |4 oth | |
| 700 | 1 | |a Yves, Gruel |e investigator |4 oth | |
| 700 | 1 | |a Faradji, Albert |e investigator |4 oth | |
| 700 | 1 | |a Aouba, Achille |e investigator |4 oth | |
| 700 | 1 | |a Trillot, Nathalie |e investigator |4 oth | |
| 700 | 1 | |a Marquès-Verdier, Alain |e investigator |4 oth | |
| 700 | 1 | |a Pouplard, Claire |e investigator |4 oth | |
| 700 | 1 | |a Zotz, Rainer |e investigator |4 oth | |
| 700 | 1 | |a Eisert, Roswith |e investigator |4 oth | |
| 700 | 1 | |a Birschmann, Ingvild |e investigator |4 oth | |
| 700 | 1 | |a von Depka Prondzinski, Mario |e investigator |4 oth | |
| 700 | 1 | |a Kirchmaier, Maximillian |e investigator |4 oth | |
| 700 | 1 | |a Rieke, Markus |e investigator |4 oth | |
| 700 | 1 | |a Pillitteri, Daniele |e investigator |4 oth | |
| 700 | 1 | |a Schlammadinger, Agota |e investigator |4 oth | |
| 700 | 1 | |a Kiss, Csongor |e investigator |4 oth | |
| 700 | 1 | |a Nemes, Laszlo |e investigator |4 oth | |
| 700 | 1 | |a Piseddu, Gavino |e investigator |4 oth | |
| 700 | 1 | |a Di Minno, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Coppola, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Giordano, Paola |e investigator |4 oth | |
| 700 | 1 | |a Sacchi, Elisabetta |e investigator |4 oth | |
| 700 | 1 | |a Schiavulli, Michele |e investigator |4 oth | |
| 700 | 1 | |a Ypma, Paula Frouke |e investigator |4 oth | |
| 700 | 1 | |a Karina, Meijer |e investigator |4 oth | |
| 700 | 1 | |a Kruip, Maria |e investigator |4 oth | |
| 700 | 1 | |a Kamphuisen, Pieter |e investigator |4 oth | |
| 700 | 1 | |a Van Gorkom, Britta Laros |e investigator |4 oth | |
| 700 | 1 | |a Hamulyak, Karly |e investigator |4 oth | |
| 700 | 1 | |a Tamminga, Rienk Yde Johan |e investigator |4 oth | |
| 700 | 1 | |a Shamsi, Tahir |e investigator |4 oth | |
| 700 | 1 | |a Borhany, Munira |e investigator |4 oth | |
| 700 | 1 | |a Garrido, Rosario Perez |e investigator |4 oth | |
| 700 | 1 | |a Jiménez-Yuste, Victor |e investigator |4 oth | |
| 700 | 1 | |a Berntorp, Erik |e investigator |4 oth | |
| 700 | 1 | |a Knobe, Karin |e investigator |4 oth | |
| 700 | 1 | |a Tsakiris, Dimitrios |e investigator |4 oth | |
| 700 | 1 | |a Brand, Brigitte |e investigator |4 oth | |
| 700 | 1 | |a Grainger, John D |e investigator |4 oth | |
| 700 | 1 | |a Khair, Kate |e investigator |4 oth | |
| 700 | 1 | |a Motwani, Jayashree |e investigator |4 oth | |
| 700 | 1 | |a Bolton-Maggs, Paula |e investigator |4 oth | |
| 700 | 1 | |a Torres, Marcella |e investigator |4 oth | |
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