Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes
AIMS/HYPOTHESIS: Hypoglycaemia is associated with reduced skin temperature (Ts). We studied whether infrared thermography can detect Ts changes during hypoglycaemia in patients with type 1 diabetes and how the Ts response differs between patients with normal hypoglycaemia awareness and hypoglycaemia unawareness.
METHODS: Twenty-four patients with type 1 diabetes (ten aware, 14 unaware) were studied during normoglycaemia (5.0-6.0 mmol/l), hypoglycaemia (2.0-2.5 mmol/l) and during recovery from hypoglycaemia (5.0-6.0 mmol/l) using hyperinsulinaemic glucose clamping. During each 1 h phase, Ts was measured twice by infrared thermography imaging in pre-defined areas (nose, glabella and the five left fingertips), symptoms of hypoglycaemia were scored and blood was sampled.
RESULTS: Ts decreased during hypoglycaemia on the nose and glabella. The highest decrements were recorded on the nose (aware: -2.6 °C, unaware: -1.1 °C). In aware patients, the differences in temperature were statistically significant on both nose and glabella, whereas there was only a trend in the unaware group. There was a significant difference in hypoglycaemia-induced temperature changes between the groups. Patients in the aware group had higher hypoglycaemia symptom scores and higher adrenaline (epinephrine) levels during hypoglycaemia.
CONCLUSIONS/INTERPRETATION: The hypoglycaemia-associated decrement in Ts can be assessed by infrared thermography and is larger in patients with normal hypoglycaemia awareness compared with unaware patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Diabetologia - 58(2015), 8 vom: 14. Aug., Seite 1898-906 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sejling, Anne-Sophie [VerfasserIn] |
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| Links: |
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| Themen: |
Blood Glucose |
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| Anmerkungen: |
Date Completed 13.04.2016 Date Revised 13.11.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00125-015-3616-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249126257 |
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| 100 | 1 | |a Sejling, Anne-Sophie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 13.04.2016 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIMS/HYPOTHESIS: Hypoglycaemia is associated with reduced skin temperature (Ts). We studied whether infrared thermography can detect Ts changes during hypoglycaemia in patients with type 1 diabetes and how the Ts response differs between patients with normal hypoglycaemia awareness and hypoglycaemia unawareness | ||
| 520 | |a METHODS: Twenty-four patients with type 1 diabetes (ten aware, 14 unaware) were studied during normoglycaemia (5.0-6.0 mmol/l), hypoglycaemia (2.0-2.5 mmol/l) and during recovery from hypoglycaemia (5.0-6.0 mmol/l) using hyperinsulinaemic glucose clamping. During each 1 h phase, Ts was measured twice by infrared thermography imaging in pre-defined areas (nose, glabella and the five left fingertips), symptoms of hypoglycaemia were scored and blood was sampled | ||
| 520 | |a RESULTS: Ts decreased during hypoglycaemia on the nose and glabella. The highest decrements were recorded on the nose (aware: -2.6 °C, unaware: -1.1 °C). In aware patients, the differences in temperature were statistically significant on both nose and glabella, whereas there was only a trend in the unaware group. There was a significant difference in hypoglycaemia-induced temperature changes between the groups. Patients in the aware group had higher hypoglycaemia symptom scores and higher adrenaline (epinephrine) levels during hypoglycaemia | ||
| 520 | |a CONCLUSIONS/INTERPRETATION: The hypoglycaemia-associated decrement in Ts can be assessed by infrared thermography and is larger in patients with normal hypoglycaemia awareness compared with unaware patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 650 | 7 | |a Insulin |2 NLM | |
| 700 | 1 | |a Lange, Kai H W |e verfasserin |4 aut | |
| 700 | 1 | |a Frandsen, Christian S |e verfasserin |4 aut | |
| 700 | 1 | |a Diemar, Sarah S |e verfasserin |4 aut | |
| 700 | 1 | |a Tarnow, Lise |e verfasserin |4 aut | |
| 700 | 1 | |a Faber, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Holst, Jens J |e verfasserin |4 aut | |
| 700 | 1 | |a Hartmann, Bolette |e verfasserin |4 aut | |
| 700 | 1 | |a Hilsted, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Kjaer, Troels W |e verfasserin |4 aut | |
| 700 | 1 | |a Juhl, Claus B |e verfasserin |4 aut | |
| 700 | 1 | |a Thorsteinsson, Birger |e verfasserin |4 aut | |
| 700 | 1 | |a Pedersen-Bjergaard, Ulrik |e verfasserin |4 aut | |
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