α-Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier
Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Medicinal chemistry (Shariqah (United Arab Emirates)) - 12(2016), 1 vom: 17., Seite 48-53 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lapidot, Inbal [VerfasserIn] |
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| Themen: |
Aminoisobutyric Acids |
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| Anmerkungen: |
Date Completed 13.02.2017 Date Revised 27.10.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249084295 |
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| 520 | |a Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Aminoisobutyric Acids |2 NLM | |
| 650 | 7 | |a Azabicyclo Compounds |2 NLM | |
| 650 | 7 | |a Bridged Bicyclo Compounds, Heterocyclic |2 NLM | |
| 650 | 7 | |a Fluorescent Dyes |2 NLM | |
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| 700 | 1 | |a Baranes, Danny |e verfasserin |4 aut | |
| 700 | 1 | |a Pinhasov, Albert |e verfasserin |4 aut | |
| 700 | 1 | |a Gellerman, Gary |e verfasserin |4 aut | |
| 700 | 1 | |a Albeck, Amnon |e verfasserin |4 aut | |
| 700 | 1 | |a Grynszpan, Flavio |e verfasserin |4 aut | |
| 700 | 1 | |a Shatzmiller, Shimon E |e verfasserin |4 aut | |
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