Compounds Combining Aminoadamantane and Monoterpene Moieties : Cytotoxicity and Mutagenic Effects
A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 µM. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50 = 12 ÷ 21 µM) along with low toxicity with respect to MDCK cells (CTD50 = 1500 µM). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Medicinal chemistry (Shariqah (United Arab Emirates)) - 11(2015), 7 vom: 17., Seite 629-35 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Suslov, Evgeniy V [VerfasserIn] |
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| Themen: |
Adamantane |
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| Anmerkungen: |
Date Completed 19.07.2016 Date Revised 27.10.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249084279 |
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| 100 | 1 | |a Suslov, Evgeniy V |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Compounds Combining Aminoadamantane and Monoterpene Moieties |b Cytotoxicity and Mutagenic Effects |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 19.07.2016 | ||
| 500 | |a Date Revised 27.10.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 µM. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50 = 12 ÷ 21 µM) along with low toxicity with respect to MDCK cells (CTD50 = 1500 µM). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Monoterpenes |2 NLM | |
| 650 | 7 | |a Mutagens |2 NLM | |
| 650 | 7 | |a Adamantane |2 NLM | |
| 650 | 7 | |a PJY633525U |2 NLM | |
| 700 | 1 | |a Ponomarev, Konstantin Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Rogachev, Artem D |e verfasserin |4 aut | |
| 700 | 1 | |a Pokrovsky, Michail A |e verfasserin |4 aut | |
| 700 | 1 | |a Pokrovsky, Andrey G |e verfasserin |4 aut | |
| 700 | 1 | |a Pykhtina, Maria B |e verfasserin |4 aut | |
| 700 | 1 | |a Beklemishev, Anatoly B |e verfasserin |4 aut | |
| 700 | 1 | |a Korchagina, Dina V |e verfasserin |4 aut | |
| 700 | 1 | |a Volcho, Konstantin P |e verfasserin |4 aut | |
| 700 | 1 | |a Salakhutdinov, Nariman F |e verfasserin |4 aut | |
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