Long-term Impact of Continuous Positive Airway Pressure Therapy on Arrhythmia and Heart Rate Variability in Patients With Sleep Apnea
Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved..
INTRODUCTION: Autonomic dysfunction can alter heart rate variability and increase the incidence of arrhythmia. We analyzed the impact of continuous positive airway pressure (CPAP) on this pathophysiological phenomenon in patients with severe sleep apnea-hypopnea syndrome.
METHODS: Consecutive patients with recently diagnosed severe sleep apnea-hypopnea syndrome were prospectively considered for inclusion. Incidence of arrhythmia and heart rate variability (recorded on a 24-hour Holter monitoring device) were analyzed before starting CPAP therapy and 1 year thereafter.
RESULTS: A total of 26 patients were included in the study. CPAP was administered for 6.6 ± 1.8 hours during Holter monitoring. After starting CPAP, we observed a marginally significant reduction in mean HR (80 ± 9 to 77 ± 11 bpm, p=.05). CPAP was associated with partial modulation (only during waking hours) of r-MSSD (p=.047) and HF (p=.025) parasympathetic parameters and LF (p=.049) sympathetic modulation parameters. None of these parameters returned completely to normal levels (p<.001). The number of unsustained episodes of atrial tachycardia diminished (p=.024), but no clear effect on other arrhythmias was observed.
CONCLUSIONS: CPAP therapy only partially improves heart rate variability, and exclusively during waking hours, and reduces incidence of atrial tachycardia, both of which can influence cardiovascular morbidity and mortality in sleep apnea-hypopnea syndrome patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Archivos de bronconeumologia - 52(2016), 1 vom: 15. Jan., Seite 17-23 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Grau, Nuria [VerfasserIn] |
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| Links: |
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| Themen: |
Apnea del sueño |
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| Anmerkungen: |
Date Completed 15.12.2016 Date Revised 30.12.2016 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.arbres.2015.03.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM248652915 |
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| 245 | 1 | 0 | |a Long-term Impact of Continuous Positive Airway Pressure Therapy on Arrhythmia and Heart Rate Variability in Patients With Sleep Apnea |
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| 500 | |a Date Revised 30.12.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved. | ||
| 520 | |a INTRODUCTION: Autonomic dysfunction can alter heart rate variability and increase the incidence of arrhythmia. We analyzed the impact of continuous positive airway pressure (CPAP) on this pathophysiological phenomenon in patients with severe sleep apnea-hypopnea syndrome | ||
| 520 | |a METHODS: Consecutive patients with recently diagnosed severe sleep apnea-hypopnea syndrome were prospectively considered for inclusion. Incidence of arrhythmia and heart rate variability (recorded on a 24-hour Holter monitoring device) were analyzed before starting CPAP therapy and 1 year thereafter | ||
| 520 | |a RESULTS: A total of 26 patients were included in the study. CPAP was administered for 6.6 ± 1.8 hours during Holter monitoring. After starting CPAP, we observed a marginally significant reduction in mean HR (80 ± 9 to 77 ± 11 bpm, p=.05). CPAP was associated with partial modulation (only during waking hours) of r-MSSD (p=.047) and HF (p=.025) parasympathetic parameters and LF (p=.049) sympathetic modulation parameters. None of these parameters returned completely to normal levels (p<.001). The number of unsustained episodes of atrial tachycardia diminished (p=.024), but no clear effect on other arrhythmias was observed | ||
| 520 | |a CONCLUSIONS: CPAP therapy only partially improves heart rate variability, and exclusively during waking hours, and reduces incidence of atrial tachycardia, both of which can influence cardiovascular morbidity and mortality in sleep apnea-hypopnea syndrome patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Apnea del sueño | |
| 650 | 4 | |a Arrhythmia | |
| 650 | 4 | |a Arritmias | |
| 650 | 4 | |a Heart rate variability | |
| 650 | 4 | |a Sleep apnea | |
| 650 | 4 | |a Variabilidad de frecuencia cardiaca | |
| 700 | 1 | |a Bazan, Victor |e verfasserin |4 aut | |
| 700 | 1 | |a Kallouchi, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez, Diego |e verfasserin |4 aut | |
| 700 | 1 | |a Estirado, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Corral, Maria Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Valls, Maria Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Sanjuas, Carles |e verfasserin |4 aut | |
| 700 | 1 | |a Felez, Miquel |e verfasserin |4 aut | |
| 700 | 1 | |a Valles, Ermengol |e verfasserin |4 aut | |
| 700 | 1 | |a Benito, Begoña |e verfasserin |4 aut | |
| 700 | 1 | |a Gea, Joaquim |e verfasserin |4 aut | |
| 700 | 1 | |a Bruguera-Cortada, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Martí-Almor, Julio |e verfasserin |4 aut | |
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