Screening for celiac disease in the general population and in high-risk groups
BACKGROUND: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death.
OBJECTIVES: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening.
METHODS: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail.
RESULTS: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective.
CONCLUSIONS: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Enthalten in: |
United European gastroenterology journal - 3(2015), 2 vom: 01. Apr., Seite 106-20 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ludvigsson, Jonas F [VerfasserIn] |
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| Links: |
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| Themen: |
Celiac disease |
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| Anmerkungen: |
Date Completed 29.04.2015 Date Revised 10.04.2022 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1177/2050640614561668 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM248519689 |
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| 100 | 1 | |a Ludvigsson, Jonas F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Screening for celiac disease in the general population and in high-risk groups |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 29.04.2015 | ||
| 500 | |a Date Revised 10.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death | ||
| 520 | |a OBJECTIVES: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening | ||
| 520 | |a METHODS: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail | ||
| 520 | |a RESULTS: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective | ||
| 520 | |a CONCLUSIONS: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Celiac disease | |
| 650 | 4 | |a World Health Organization | |
| 650 | 4 | |a gluten | |
| 650 | 4 | |a gluten-free diet | |
| 650 | 4 | |a prevention | |
| 650 | 4 | |a quality of life | |
| 650 | 4 | |a review | |
| 650 | 4 | |a risk | |
| 650 | 4 | |a screening | |
| 700 | 1 | |a Card, Timothy R |e verfasserin |4 aut | |
| 700 | 1 | |a Kaukinen, Katri |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Julio |e verfasserin |4 aut | |
| 700 | 1 | |a Zingone, Fabiana |e verfasserin |4 aut | |
| 700 | 1 | |a Sanders, David S |e verfasserin |4 aut | |
| 700 | 1 | |a Murray, Joseph A |e verfasserin |4 aut | |
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