Multifunctional polymer-capped mesoporous silica nanoparticles for pH-responsive targeted drug delivery
A highly stable modular platform, based on the sequential covalent attachment of different functionalities to the surface of core-shell mesoporous silica nanoparticles (MSNs) for targeted drug delivery is presented. A reversible pH-responsive cap system based on covalently attached poly(2-vinylpyridine) (PVP) was developed as drug release mechanism. Our platform offers (i) tuneable interactions and release kinetics with the cargo drug in the mesopores based on chemically orthogonal core-shell design, (ii) an extremely robust and reversible closure and release mechanism based on endosomal acidification of the covalently attached PVP polymer block, (iii) high colloidal stability due to a covalently coupled PEG shell, and (iv) the ability to covalently attach a wide variety of dyes, targeting ligands and other functionalities at the outer periphery of the PEG shell. The functionality of the system was demonstrated in several cell studies, showing pH-triggered release in the endosome, light-triggered endosomal escape with an on-board photosensitizer, and efficient folic acid-based cell targeting.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Nanoscale - 7(2015), 17 vom: 07. Mai, Seite 7953-64 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Niedermayer, Stefan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 23.02.2016 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.1039/c4nr07245f |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM247974188 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A highly stable modular platform, based on the sequential covalent attachment of different functionalities to the surface of core-shell mesoporous silica nanoparticles (MSNs) for targeted drug delivery is presented. A reversible pH-responsive cap system based on covalently attached poly(2-vinylpyridine) (PVP) was developed as drug release mechanism. Our platform offers (i) tuneable interactions and release kinetics with the cargo drug in the mesopores based on chemically orthogonal core-shell design, (ii) an extremely robust and reversible closure and release mechanism based on endosomal acidification of the covalently attached PVP polymer block, (iii) high colloidal stability due to a covalently coupled PEG shell, and (iv) the ability to covalently attach a wide variety of dyes, targeting ligands and other functionalities at the outer periphery of the PEG shell. The functionality of the system was demonstrated in several cell studies, showing pH-triggered release in the endosome, light-triggered endosomal escape with an on-board photosensitizer, and efficient folic acid-based cell targeting | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Fluorescent Dyes |2 NLM | |
| 650 | 7 | |a Polyvinyls |2 NLM | |
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| 700 | 1 | |a Weiss, Veronika |e verfasserin |4 aut | |
| 700 | 1 | |a Herrmann, Annika |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Datz, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Müller, Katharina |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Ernst |e verfasserin |4 aut | |
| 700 | 1 | |a Bein, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Bräuchle, Christoph |e verfasserin |4 aut | |
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