Treatment interruption and directly observed treatment of multidrug-resistant tuberculosis patients in China
BACKGROUND: China has nearly one fifth of global multidrug-resistant tuberculosis (MDR-TB) cases, and follows the 24-month World Health Organization (WHO) standardised regimens.
OBJECTIVE: To assess treatment interruption among MDR-TB patients and its association with the provision of directly observed treatment (DOT).
METHODS: We reviewed clinical charts and conducted a questionnaire survey among all confirmed MDR-TB patients who had been treated for at least 6 months from 1 January 2009 to 30 April 2012 in Shandong Province. Treatment interruption was defined as missing a dose for at least 1 day but for <8 consecutive weeks; the subset 'severe interruption' was defined as missing doses for 2-8 consecutive weeks.
RESULTS: Of 110 patients, 75 (68%) interrupted treatment; 19 (17%) reported severe interruption, with a median duration of 30 days. Of the 110 patients, 26 (24%) received injections from family members and 55 (50%) received DOT, 7 (13%) from village doctors and 48 (87%) from family members. Patients who underwent DOT with a family member had less severe interruptions (OR 0.25, 95%CI 0.05-0.98) than those who were given DOT by a village doctor or who did not undergo DOT.
CONCLUSIONS: Family members may act as treatment supporters for MDR-TB patients to reduce treatment interruptions, but require orientation on their role.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 19(2015), 4 vom: 22. Apr., Seite 413-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wei, X-L [VerfasserIn] |
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| Links: |
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| Themen: |
Antitubercular Agents |
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| Anmerkungen: |
Date Completed 07.01.2016 Date Revised 09.04.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.5588/ijtld.14.0485 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM247915661 |
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| 245 | 1 | 0 | |a Treatment interruption and directly observed treatment of multidrug-resistant tuberculosis patients in China |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 07.01.2016 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: China has nearly one fifth of global multidrug-resistant tuberculosis (MDR-TB) cases, and follows the 24-month World Health Organization (WHO) standardised regimens | ||
| 520 | |a OBJECTIVE: To assess treatment interruption among MDR-TB patients and its association with the provision of directly observed treatment (DOT) | ||
| 520 | |a METHODS: We reviewed clinical charts and conducted a questionnaire survey among all confirmed MDR-TB patients who had been treated for at least 6 months from 1 January 2009 to 30 April 2012 in Shandong Province. Treatment interruption was defined as missing a dose for at least 1 day but for <8 consecutive weeks; the subset 'severe interruption' was defined as missing doses for 2-8 consecutive weeks | ||
| 520 | |a RESULTS: Of 110 patients, 75 (68%) interrupted treatment; 19 (17%) reported severe interruption, with a median duration of 30 days. Of the 110 patients, 26 (24%) received injections from family members and 55 (50%) received DOT, 7 (13%) from village doctors and 48 (87%) from family members. Patients who underwent DOT with a family member had less severe interruptions (OR 0.25, 95%CI 0.05-0.98) than those who were given DOT by a village doctor or who did not undergo DOT | ||
| 520 | |a CONCLUSIONS: Family members may act as treatment supporters for MDR-TB patients to reduce treatment interruptions, but require orientation on their role | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antitubercular Agents |2 NLM | |
| 700 | 1 | |a Yin, J |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, G-Y |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Z-T |e verfasserin |4 aut | |
| 700 | 1 | |a Walley, J |e verfasserin |4 aut | |
| 700 | 1 | |a Harwell, J |e verfasserin |4 aut | |
| 700 | 1 | |a Li, H-T |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Q |e verfasserin |4 aut | |
| 700 | 1 | |a Li, R-Z |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, L-X |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, X-L |e verfasserin |4 aut | |
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