Why "R" HIT patients predisposed to thrombosis?
In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating the thrombotic process.
| Errataetall: |
CommentOn: Blood. 2015 Apr 9;125(15):2397-404. - PMID 25680756 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:125 |
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| Enthalten in: |
Blood - 125(2015), 15 vom: 09. Apr., Seite 2319-20 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Padmanabhan, Anand [VerfasserIn] |
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| Links: |
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| Themen: |
9005-49-6 |
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| Anmerkungen: |
Date Completed 23.06.2015 Date Revised 02.02.2021 published: Print CommentOn: Blood. 2015 Apr 9;125(15):2397-404. - PMID 25680756 Citation Status MEDLINE |
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| doi: |
10.1182/blood-2015-02-629782 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM247904783 |
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| 520 | |a In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating the thrombotic process | ||
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