Discovery of a P450-catalyzed step in vindoline biosynthesis : a link between the aspidosperma and eburnamine alkaloids
Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzyme catalyzes the formation of an epoxide that can undergo rearrangement to yield the vincamine-eburnamine backbone, thereby providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 51(2015), 36 vom: 04. Mai, Seite 7626-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kellner, Franziska [VerfasserIn] |
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| Links: |
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| Themen: |
571PJ1LW03 |
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| Anmerkungen: |
Date Completed 01.02.2016 Date Revised 16.07.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1039/c5cc01309g |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM247820024 |
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| 520 | |a Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzyme catalyzes the formation of an epoxide that can undergo rearrangement to yield the vincamine-eburnamine backbone, thereby providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Vinca Alkaloids |2 NLM | |
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| 700 | 1 | |a Geu-Flores, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Sherden, Nathaniel H |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Foureau, Emilien |e verfasserin |4 aut | |
| 700 | 1 | |a Courdavault, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a O'Connor, Sarah E |e verfasserin |4 aut | |
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