Restoring susceptibility induced MRI signal loss in rat brain at 9.4 T : A step towards whole brain functional connectivity imaging
The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
PloS one - 10(2015), 4 vom: 28., Seite e0119450 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Rupeng [VerfasserIn] |
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| Links: |
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| Themen: |
Fluorocarbons |
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| Anmerkungen: |
Date Completed 05.04.2016 Date Revised 06.03.2020 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0119450 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM247769509 |
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| 245 | 1 | 0 | |a Restoring susceptibility induced MRI signal loss in rat brain at 9.4 T |b A step towards whole brain functional connectivity imaging |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 7 | |a Fluorocarbons |2 NLM | |
| 700 | 1 | |a Liu, Xiping |e verfasserin |4 aut | |
| 700 | 1 | |a Sidabras, Jason W |e verfasserin |4 aut | |
| 700 | 1 | |a Paulson, Eric S |e verfasserin |4 aut | |
| 700 | 1 | |a Jesmanowicz, Andrzej |e verfasserin |4 aut | |
| 700 | 1 | |a Nencka, Andrew S |e verfasserin |4 aut | |
| 700 | 1 | |a Hudetz, Anthony G |e verfasserin |4 aut | |
| 700 | 1 | |a Hyde, James S |e verfasserin |4 aut | |
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