SUMO-mediated regulation of DNA damage repair and responses
Copyright © 2015 Elsevier Ltd. All rights reserved..
Sumoylation has important roles during DNA damage repair and responses. Recent broad-scope and substrate-based studies have shed light on the regulation and significance of sumoylation during these processes. An emerging paradigm is that sumoylation of many DNA metabolism proteins is controlled by DNA engagement. Such 'on-site modification' can explain low substrate modification levels and has important implications in sumoylation mechanisms and effects. New studies also suggest that sumoylation can regulate a process through an ensemble effect or via major substrates. Additionally, we describe new trends in the functional effects of sumoylation, such as bi-directional changes in biomolecule binding and multilevel coordination with other modifications. These emerging themes and models will stimulate our thinking and research in sumoylation and genome maintenance.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Trends in biochemical sciences - 40(2015), 4 vom: 15. Apr., Seite 233-42 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sarangi, Prabha [VerfasserIn] |
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Journal Article |
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| Anmerkungen: |
Date Completed 28.09.2015 Date Revised 30.06.2021 published: Print-Electronic ErratumIn: Trends Biochem Sci. 2015 Jun;40(6):338 Citation Status MEDLINE |
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| doi: |
10.1016/j.tibs.2015.02.006 |
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| 520 | |a Sumoylation has important roles during DNA damage repair and responses. Recent broad-scope and substrate-based studies have shed light on the regulation and significance of sumoylation during these processes. An emerging paradigm is that sumoylation of many DNA metabolism proteins is controlled by DNA engagement. Such 'on-site modification' can explain low substrate modification levels and has important implications in sumoylation mechanisms and effects. New studies also suggest that sumoylation can regulate a process through an ensemble effect or via major substrates. Additionally, we describe new trends in the functional effects of sumoylation, such as bi-directional changes in biomolecule binding and multilevel coordination with other modifications. These emerging themes and models will stimulate our thinking and research in sumoylation and genome maintenance | ||
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