Nocturnal Hypoxemia and Severe Obstructive Sleep Apnea are Associated with Incident Type 2 Diabetes in a Population Cohort of Men
© 2015 American Academy of Sleep Medicine..
STUDY OBJECTIVES: Studies examining the longitudinal association of untreated obstructive sleep apnea (OSA) with diabetes in population samples are limited. This study therefore examined the relationship between previously undiagnosed OSA with incident type 2 diabetes in community-dwelling men aged ≥ 40 y.
METHODS: The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study is a longitudinal population-based cohort in Adelaide, South Australia. Clinic assessments at baseline and follow-up identified diabetes (self-reported doctor diagnosed, fasting plasma glucose ≥ 7.0 mmol/L, glycated hemoglobin ≥ 6.5% or diabetes medication use) and included anthropometry. At cohort follow-up (2010-2012), n = 837 underwent full in-home unattended polysomnography (PSG, Embletta X100, Broomfield, CO).
RESULTS: Of 736 men free of diabetes at baseline, incident diabetes occurred in 66 (9.0%) over a mean follow-up time of 56 mo (standard deviation = 5, range: 48-74 mo). Incident diabetes was associated with current oxygen desaturation index (3%) ≥ 16 events/h (odds ratio [OR]: 1.85 [1.06-3.21]), and severe OSA [OR: 2.6 (1.1-6.1)], in adjusted models including age, percentage total body fat, and weight gain (> 5 cm waist circumference). An age-adjusted association of incident diabetes with percentage of total sleep time with oxygen saturation < 90% did not persist after adjustment for percentage of body fat. No modification of these relationships by excessive daytime sleepiness was observed.
CONCLUSIONS: Severe undiagnosed OSA and nocturnal hypoxemia were independently associated with the development of diabetes. A reduction in the burden of undiagnosed OSA and undiagnosed diabetes is likely to occur if patients presenting with one disorder are assessed for the other.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2015 |
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Erschienen: |
2015 |
Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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Enthalten in: |
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine - 11(2015), 6 vom: 15. Juni, Seite 609-14 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Appleton, Sarah L [VerfasserIn] |
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Links: |
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Themen: |
Cohort study |
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Anmerkungen: |
Date Completed 04.04.2016 Date Revised 21.03.2022 published: Electronic Citation Status MEDLINE |
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doi: |
10.5664/jcsm.4768 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM247040258 |
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520 | |a © 2015 American Academy of Sleep Medicine. | ||
520 | |a STUDY OBJECTIVES: Studies examining the longitudinal association of untreated obstructive sleep apnea (OSA) with diabetes in population samples are limited. This study therefore examined the relationship between previously undiagnosed OSA with incident type 2 diabetes in community-dwelling men aged ≥ 40 y | ||
520 | |a METHODS: The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study is a longitudinal population-based cohort in Adelaide, South Australia. Clinic assessments at baseline and follow-up identified diabetes (self-reported doctor diagnosed, fasting plasma glucose ≥ 7.0 mmol/L, glycated hemoglobin ≥ 6.5% or diabetes medication use) and included anthropometry. At cohort follow-up (2010-2012), n = 837 underwent full in-home unattended polysomnography (PSG, Embletta X100, Broomfield, CO) | ||
520 | |a RESULTS: Of 736 men free of diabetes at baseline, incident diabetes occurred in 66 (9.0%) over a mean follow-up time of 56 mo (standard deviation = 5, range: 48-74 mo). Incident diabetes was associated with current oxygen desaturation index (3%) ≥ 16 events/h (odds ratio [OR]: 1.85 [1.06-3.21]), and severe OSA [OR: 2.6 (1.1-6.1)], in adjusted models including age, percentage total body fat, and weight gain (> 5 cm waist circumference). An age-adjusted association of incident diabetes with percentage of total sleep time with oxygen saturation < 90% did not persist after adjustment for percentage of body fat. No modification of these relationships by excessive daytime sleepiness was observed | ||
520 | |a CONCLUSIONS: Severe undiagnosed OSA and nocturnal hypoxemia were independently associated with the development of diabetes. A reduction in the burden of undiagnosed OSA and undiagnosed diabetes is likely to occur if patients presenting with one disorder are assessed for the other | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a cohort study | |
650 | 4 | |a epidemiology | |
650 | 4 | |a men | |
650 | 4 | |a nocturnal hypoxemia | |
650 | 4 | |a obstructive sleep apnea | |
650 | 4 | |a polysomnography | |
650 | 4 | |a type 2 diabetes | |
700 | 1 | |a Vakulin, Andrew |e verfasserin |4 aut | |
700 | 1 | |a McEvoy, R Doug |e verfasserin |4 aut | |
700 | 1 | |a Wittert, Gary A |e verfasserin |4 aut | |
700 | 1 | |a Martin, Sean A |e verfasserin |4 aut | |
700 | 1 | |a Grant, Janet F |e verfasserin |4 aut | |
700 | 1 | |a Taylor, Anne W |e verfasserin |4 aut | |
700 | 1 | |a Antic, Nick A |e verfasserin |4 aut | |
700 | 1 | |a Catcheside, Peter G |e verfasserin |4 aut | |
700 | 1 | |a Adams, Robert J |e verfasserin |4 aut | |
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