HCMV infections after hematopoietic stem cell transplantation--diagnostic methods and importance of viral DNA level monitoring
HCMV infection is very common. The virus infects 30-90% of population. In immunocompromised patients effective elimination of the virus by immune system is limited by immunosuppressive therapy. Active hCMV infection after HSCT can lead to severe posttransplant complications, graft failure or even death. In addition to direct effects of hCMV infection the virus can cause indirect effects in transplant recipients such as increased immunosuppression or GvHD development/progression. Laboratory diagnostic of hCMV infections after HSCT is now routinely used. Fast and sensitive molecular methods that detect hCMV genetic material are found particularly useful. Quantitative methods, such as R-T PCR, enable identification of patients at high risk of developing hCMV disease and fast employment of appropriate prophylaxis or treatment. Moreover it allows precise monitoring of treatment efficiency and facilitates therapy - related decisions. In last years pre-emptive therapy, which depends on viral load molecular monitoring, significantly reduced morbidity and mortality of active hCMV infections in HSCT recipients. Selective prophylaxis approach enables reduction of patients treated with toxic antiviral therapy which is associated with delayed restoration of virus - specific immune response. Occurrence of symptomatic hCMV disease is still associated with high mortality among HSCT recipients. HCMV infection diagnosis requires further development. Quantitative methods should be unified and optimized.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Postepy higieny i medycyny doswiadczalnej (Online) - 69(2015) vom: 21. Feb., Seite 252-63 |
| Sprache: |
Polnisch |
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| Weiterer Titel: |
Infekcje ludzkim wirusem cytomegalii po transplantacji macierzystych komórek krwiotwórczych – metody diagnostyczne i znaczenie monitorowania poziomu DNA wirusa |
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| Beteiligte Personen: |
Bocian, Joanna [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 11.08.2015 Date Revised 03.12.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.5604/17322693.1141100 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM246594454 |
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| 245 | 1 | 0 | |a HCMV infections after hematopoietic stem cell transplantation--diagnostic methods and importance of viral DNA level monitoring |
| 246 | 3 | 3 | |a Infekcje ludzkim wirusem cytomegalii po transplantacji macierzystych komórek krwiotwórczych – metody diagnostyczne i znaczenie monitorowania poziomu DNA wirusa |
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| 520 | |a HCMV infection is very common. The virus infects 30-90% of population. In immunocompromised patients effective elimination of the virus by immune system is limited by immunosuppressive therapy. Active hCMV infection after HSCT can lead to severe posttransplant complications, graft failure or even death. In addition to direct effects of hCMV infection the virus can cause indirect effects in transplant recipients such as increased immunosuppression or GvHD development/progression. Laboratory diagnostic of hCMV infections after HSCT is now routinely used. Fast and sensitive molecular methods that detect hCMV genetic material are found particularly useful. Quantitative methods, such as R-T PCR, enable identification of patients at high risk of developing hCMV disease and fast employment of appropriate prophylaxis or treatment. Moreover it allows precise monitoring of treatment efficiency and facilitates therapy - related decisions. In last years pre-emptive therapy, which depends on viral load molecular monitoring, significantly reduced morbidity and mortality of active hCMV infections in HSCT recipients. Selective prophylaxis approach enables reduction of patients treated with toxic antiviral therapy which is associated with delayed restoration of virus - specific immune response. Occurrence of symptomatic hCMV disease is still associated with high mortality among HSCT recipients. HCMV infection diagnosis requires further development. Quantitative methods should be unified and optimized | ||
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