Brain Magnetic Resonance Spectroscopy Findings in the Stroke-like Migraine Attacks after Radiation Therapy (SMART) Syndrome
Copyright © 2015 by the American Society of Neuroimaging..
A 41-year-old male presented with an acute onset of headache, confusion, seizures, and unilateral focal neurological deficit 25 years after receiving whole-brain radiation therapy to treat a cerebellar medulloblastoma. Brain magnetic resonance imaging (MRI) demonstrated a thick unilateral parieto-occipital cortical contrast enhancement. A diagnosis of "Stroke-like Migraine Attacks after Radiation Therapy" (SMART) syndrome was made. Here, we describe the brain MR spectroscopy findings of SMART, showing a decrease in N-acetyl-aspartate and increased levels of creatine and choline, corresponding with neuronal destruction or transient neuronal impairment with mild nonspecific gliosis. The absence of a lactate peak suggests that mitochondrial dysfunction, vasospasm or ischemic mechanisms were not involved.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Journal of neuroimaging : official journal of the American Society of Neuroimaging - 25(2015), 6 vom: 21. Nov., Seite 1056-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gómez-Cibeira, Emilio [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 13.12.2016 Date Revised 30.12.2016 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/jon.12227 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM246440007 |
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| 520 | |a Copyright © 2015 by the American Society of Neuroimaging. | ||
| 520 | |a A 41-year-old male presented with an acute onset of headache, confusion, seizures, and unilateral focal neurological deficit 25 years after receiving whole-brain radiation therapy to treat a cerebellar medulloblastoma. Brain magnetic resonance imaging (MRI) demonstrated a thick unilateral parieto-occipital cortical contrast enhancement. A diagnosis of "Stroke-like Migraine Attacks after Radiation Therapy" (SMART) syndrome was made. Here, we describe the brain MR spectroscopy findings of SMART, showing a decrease in N-acetyl-aspartate and increased levels of creatine and choline, corresponding with neuronal destruction or transient neuronal impairment with mild nonspecific gliosis. The absence of a lactate peak suggests that mitochondrial dysfunction, vasospasm or ischemic mechanisms were not involved | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a SMART | |
| 650 | 4 | |a magnetic resonance spectroscopy | |
| 650 | 4 | |a radiation therapy | |
| 650 | 4 | |a stroke-like migraine attacks after radiation therapy | |
| 700 | 1 | |a Calleja-Castaño, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Gonzalez de la Aleja, Jesus |e verfasserin |4 aut | |
| 700 | 1 | |a Sierra-Hidalgo, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz Morales, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Salvador-Alvarez, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos-Gonzalez, Ana |e verfasserin |4 aut | |
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