One-pot synthesis of 3,5-disubstituted and polysubstituted phenols from acyclic precursors
A new strategy for the synthesis of 3,5-disubstituted phenols is established through one-pot Robinson annulation of α,β-unsaturated ketones with α-fluoro-β-ketoesters followed by in situ dehydrofluorination and tautomerization. This method has been extended to the synthesis of polysubstituted phenols and applied in the preparation of biologically active compounds.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Organic letters - 17(2015), 5 vom: 06. März, Seite 1090-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Qian, Jinlong [VerfasserIn] |
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| Links: |
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| Themen: |
Esters |
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| Anmerkungen: |
Date Completed 31.08.2015 Date Revised 06.03.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/ol503615n |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM246172924 |
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| 520 | |a A new strategy for the synthesis of 3,5-disubstituted phenols is established through one-pot Robinson annulation of α,β-unsaturated ketones with α-fluoro-β-ketoesters followed by in situ dehydrofluorination and tautomerization. This method has been extended to the synthesis of polysubstituted phenols and applied in the preparation of biologically active compounds | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Yi, Wenbin |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Miao, Yongbo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Junkai |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wei |e verfasserin |4 aut | |
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