Anti-hyperlipidemic effect of methanol bark extract of Terminalia chebula in male albino Wistar rats
CONTEXT: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects.
OBJECTIVE: Terminalia chebula Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of T. chebula.
MATERIALS AND METHODS: Acute toxicity studies were performed according to the Organisation for Economic Cooperation and Development (OECD) guideline no. 423 using various doses (5, 50, 300, and 2000 mg/kg) of T. chebula bark. Anti-hyperlipidemic effect of MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg and fasting glucose levels after treatment with MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg were analyzed using commercially available kits.
RESULTS: Acute toxicity studies did not show any morbidity and mortality at various doses. The MeOH extract of T. chebula bark at doses of 200, 400, and 600 mg/kg significantly lowered serum cholesterol and triglyceride levels. Moreover, the extract of T. chebula and the positive control atorvastatin-treated groups of animals showed a significant increase in the serum high-density lipoprotein (HDL) cholesterol levels in diet-induced hypercholesterolemic animals.
CONCLUSION: The overall results confirm that the bark extract of T. chebula possesses significant anti-hyperlipidemic activity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Pharmaceutical biology - 53(2015), 8 vom: 23. Aug., Seite 1133-40 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Reddy, Murali Mohan [VerfasserIn] |
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| Links: |
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| Themen: |
Acute toxicity study |
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| Anmerkungen: |
Date Completed 01.03.2016 Date Revised 05.06.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3109/13880209.2014.962058 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM245700889 |
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| 500 | |a Date Revised 05.06.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a CONTEXT: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects | ||
| 520 | |a OBJECTIVE: Terminalia chebula Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of T. chebula | ||
| 520 | |a MATERIALS AND METHODS: Acute toxicity studies were performed according to the Organisation for Economic Cooperation and Development (OECD) guideline no. 423 using various doses (5, 50, 300, and 2000 mg/kg) of T. chebula bark. Anti-hyperlipidemic effect of MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg and fasting glucose levels after treatment with MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg were analyzed using commercially available kits | ||
| 520 | |a RESULTS: Acute toxicity studies did not show any morbidity and mortality at various doses. The MeOH extract of T. chebula bark at doses of 200, 400, and 600 mg/kg significantly lowered serum cholesterol and triglyceride levels. Moreover, the extract of T. chebula and the positive control atorvastatin-treated groups of animals showed a significant increase in the serum high-density lipoprotein (HDL) cholesterol levels in diet-induced hypercholesterolemic animals | ||
| 520 | |a CONCLUSION: The overall results confirm that the bark extract of T. chebula possesses significant anti-hyperlipidemic activity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute toxicity study | |
| 650 | 4 | |a MeOH bark extract | |
| 650 | 4 | |a anti-hyperlipidemic property | |
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| 700 | 1 | |a Dhas, Jebasingh |e verfasserin |4 aut | |
| 700 | 1 | |a Adeghate, Ernest |e verfasserin |4 aut | |
| 700 | 1 | |a Starling Emerald, Bright |e verfasserin |4 aut | |
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