Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice
Copyright © 2015 Elsevier B.V. All rights reserved..
Coumarins are an important group of bioactive constituents in licorice (Glycyrrhiza uralensis), a worldwide popular herbal medicine. This study aims to elucidate the metabolism of two major licorice coumarins, glycyrin and glycyrol in rats. After oral administration of 40mg/kg glycyrin, neither the parent compound nor its metabolites could be detected in rats plasma or urine samples, indicating that glycyrin had poor oral bioavailability. Two hydroxylated metabolites, 4″-hydroxyl glycyrin and 5″-hydroxyl glycyrin, were detected in rat liver microsome incubation system. Among them, the major metabolite 4″-hydroxyl glycyrin, which is a new compound, was obtained by microbial transformation of Syncephalastrum racemosum AS 3.264. Its structure was fully identified by 1D and 2D NMR. Meanwhile, glycyrol, together with three metabolites, were detected in rats urine and fecal samples after oral administration (40mg/kg). Their structures were tentatively characterized by LC/MS. Glycyrol mainly undertakes hydroxylation metabolism, accompanied by hydration and dehydrogenation as minor reactions. This is the first systematic study on metabolism of glycyrin and glycyrol. The results could be valuable to evaluate druggability of these bioactive natural products.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2015 |
---|---|
Erschienen: |
2015 |
Enthalten in: |
Zur Gesamtaufnahme - volume:983-984 |
---|---|
Enthalten in: |
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 983-984(2015) vom: 01. März, Seite 39-46 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Wang, Qi [VerfasserIn] |
---|
Links: |
---|
Themen: |
994BQ9M3AV |
---|
Anmerkungen: |
Date Completed 19.10.2015 Date Revised 13.12.2018 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.jchromb.2014.12.028 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM245594450 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM245594450 | ||
003 | DE-627 | ||
005 | 20231224141219.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2015 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.jchromb.2014.12.028 |2 doi | |
028 | 5 | 2 | |a pubmed24n0818.xml |
035 | |a (DE-627)NLM245594450 | ||
035 | |a (NLM)25614969 | ||
035 | |a (PII)S1570-0232(15)00012-4 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Wang, Qi |e verfasserin |4 aut | |
245 | 1 | 0 | |a Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice |
264 | 1 | |c 2015 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 19.10.2015 | ||
500 | |a Date Revised 13.12.2018 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2015 Elsevier B.V. All rights reserved. | ||
520 | |a Coumarins are an important group of bioactive constituents in licorice (Glycyrrhiza uralensis), a worldwide popular herbal medicine. This study aims to elucidate the metabolism of two major licorice coumarins, glycyrin and glycyrol in rats. After oral administration of 40mg/kg glycyrin, neither the parent compound nor its metabolites could be detected in rats plasma or urine samples, indicating that glycyrin had poor oral bioavailability. Two hydroxylated metabolites, 4″-hydroxyl glycyrin and 5″-hydroxyl glycyrin, were detected in rat liver microsome incubation system. Among them, the major metabolite 4″-hydroxyl glycyrin, which is a new compound, was obtained by microbial transformation of Syncephalastrum racemosum AS 3.264. Its structure was fully identified by 1D and 2D NMR. Meanwhile, glycyrol, together with three metabolites, were detected in rats urine and fecal samples after oral administration (40mg/kg). Their structures were tentatively characterized by LC/MS. Glycyrol mainly undertakes hydroxylation metabolism, accompanied by hydration and dehydrogenation as minor reactions. This is the first systematic study on metabolism of glycyrin and glycyrol. The results could be valuable to evaluate druggability of these bioactive natural products | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Coumarin | |
650 | 4 | |a Glycyrin | |
650 | 4 | |a Glycyrol | |
650 | 4 | |a Glycyrrhiza uralensis | |
650 | 4 | |a Metabolites identification | |
650 | 7 | |a Coumarins |2 NLM | |
650 | 7 | |a Flavonoids |2 NLM | |
650 | 7 | |a glycyrol |2 NLM | |
650 | 7 | |a glycyrin |2 NLM | |
650 | 7 | |a 994BQ9M3AV |2 NLM | |
700 | 1 | |a Qiao, Xue |e verfasserin |4 aut | |
700 | 1 | |a Qian, Yi |e verfasserin |4 aut | |
700 | 1 | |a Liu, Chun-fang |e verfasserin |4 aut | |
700 | 1 | |a Yang, Yan-fang |e verfasserin |4 aut | |
700 | 1 | |a Ji, Shuai |e verfasserin |4 aut | |
700 | 1 | |a Li, Jun |e verfasserin |4 aut | |
700 | 1 | |a Guo, De-an |e verfasserin |4 aut | |
700 | 1 | |a Ye, Min |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |d 2002 |g 983-984(2015) vom: 01. März, Seite 39-46 |w (DE-627)NLM117075906 |x 1873-376X |7 nnns |
773 | 1 | 8 | |g volume:983-984 |g year:2015 |g day:01 |g month:03 |g pages:39-46 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jchromb.2014.12.028 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 983-984 |j 2015 |b 01 |c 03 |h 39-46 |