The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS) : A survey of 247 consecutive cases
Copyright © 2015 Elsevier B.V. All rights reserved..
AIM: To analyse the clinical features, laboratory data, foetal-maternal outcomes, and follow-up in a cohort of 247 women with obstetric antiphospholipid syndrome (OAPS).
METHODS: The European Registry on APS became a Registry within the framework of the European Forum on Antiphospholipid Antibody projects and placed on a website in June 2010. Cases with obstetric complaints related to aPL who tested positive for aPL prospectively and retrospectively were included. The three-year survey results are reported.
RESULTS: 338 women with 1253 pregnancy episodes were included; 915 were historical and 338 were latest episodes. All these women tested positive for aPL. 247 of the 338 fulfilled the Sydney criteria. According to the laboratory categories, 84/247 were in category I, 42 in IIa, 66 in IIb and 55 in IIc. Obstetric complications other than foetal losses, appeared in 129 cases (52.2%). 192 (77.7%) had a live birth and 55 (22.3%) did not. The latter group of only 38 cases (69%) received adequate treatment and 17 (31%) did not. 177/247 (72%) women were put on heparin plus LDA. Thrombosis appeared in two during pregnancy and in 14 during the puerperium. 7 (3%) women evolved to complete SLE.
CONCLUSIONS: OAPS shows differential characteristics than classical APS. All laboratory test categories are needed to avoid false-negative diagnoses. In some cases, complement levels could act as a serological marker. OAPS has very good foetal-maternal outcomes when treated. Thrombosis and progression to SLE in mothers with OAPS are scarce compared with "classical APS", suggesting that they have different aPL-mediated pathogenic mechanisms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Autoimmunity reviews - 14(2015), 5 vom: 12. Mai, Seite 387-95 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alijotas-Reig, Jaume [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.07.2015 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.autrev.2014.12.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM245028951 |
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| 100 | 1 | |a Alijotas-Reig, Jaume |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS) |b A survey of 247 consecutive cases |
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| 500 | |a Date Completed 27.07.2015 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier B.V. All rights reserved. | ||
| 520 | |a AIM: To analyse the clinical features, laboratory data, foetal-maternal outcomes, and follow-up in a cohort of 247 women with obstetric antiphospholipid syndrome (OAPS) | ||
| 520 | |a METHODS: The European Registry on APS became a Registry within the framework of the European Forum on Antiphospholipid Antibody projects and placed on a website in June 2010. Cases with obstetric complaints related to aPL who tested positive for aPL prospectively and retrospectively were included. The three-year survey results are reported | ||
| 520 | |a RESULTS: 338 women with 1253 pregnancy episodes were included; 915 were historical and 338 were latest episodes. All these women tested positive for aPL. 247 of the 338 fulfilled the Sydney criteria. According to the laboratory categories, 84/247 were in category I, 42 in IIa, 66 in IIb and 55 in IIc. Obstetric complications other than foetal losses, appeared in 129 cases (52.2%). 192 (77.7%) had a live birth and 55 (22.3%) did not. The latter group of only 38 cases (69%) received adequate treatment and 17 (31%) did not. 177/247 (72%) women were put on heparin plus LDA. Thrombosis appeared in two during pregnancy and in 14 during the puerperium. 7 (3%) women evolved to complete SLE | ||
| 520 | |a CONCLUSIONS: OAPS shows differential characteristics than classical APS. All laboratory test categories are needed to avoid false-negative diagnoses. In some cases, complement levels could act as a serological marker. OAPS has very good foetal-maternal outcomes when treated. Thrombosis and progression to SLE in mothers with OAPS are scarce compared with "classical APS", suggesting that they have different aPL-mediated pathogenic mechanisms | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Antiphospholipid antibody | |
| 650 | 4 | |a Laboratory categories | |
| 650 | 4 | |a Obstetric antiphospholipid syndrome | |
| 650 | 4 | |a Obstetric morbidity | |
| 650 | 4 | |a Registry | |
| 650 | 4 | |a Treatment | |
| 650 | 7 | |a Antibodies, Antiphospholipid |2 NLM | |
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| 700 | 1 | |a Ruffatti, Amelia |e verfasserin |4 aut | |
| 700 | 1 | |a Tincani, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Lefkou, Elmina |e verfasserin |4 aut | |
| 700 | 1 | |a Bertero, Ma Tiziana |e verfasserin |4 aut | |
| 700 | 1 | |a Coloma-Bazan, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a de Carolis, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Espinosa, Gerard |e verfasserin |4 aut | |
| 700 | 1 | |a Rovere-Querini, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Kuzenko, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Valverde, Enrique E |e verfasserin |4 aut | |
| 700 | 1 | |a Robles, Angel |e verfasserin |4 aut | |
| 700 | 1 | |a Cervera, Ricard |e verfasserin |4 aut | |
| 700 | 1 | |a Canti, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Fredi, Micaela |e verfasserin |4 aut | |
| 700 | 1 | |a Gil-Aguado, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Lundelin, Krista |e verfasserin |4 aut | |
| 700 | 1 | |a Llurba, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Melnychuk, Taisiya |e verfasserin |4 aut | |
| 700 | 1 | |a Nalli, Cecilia |e verfasserin |4 aut | |
| 700 | 1 | |a Picardo, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Silvestro, Erika |e verfasserin |4 aut | |
| 700 | 1 | |a del Ross, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Farran-Codina, Inmaculada |e verfasserin |4 aut | |
| 700 | 0 | |a (EUROAPS Study Group Collaborators) |e verfasserin |4 aut | |
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