Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy
© 2014 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)..
We report the first successful transplantation of cryopreserved ovarian cortical tissue into heavily irradiated tissues in a patient who had received sterilizing pelvic radiotherapy (54 Gy) and 40 weeks of intensive high-dose chemotherapy for the treatment of Ewing's sarcoma 14 years earlier. Repeated transplantation procedures were required to obtain fully functional follicular development. Enlargement of the transplants over time and increase of the size of the uterus were demonstrated on sequential ultrasonographic examinations. Eggs of good quality that could be fertilized in vitro were obtained only after a substantial incremental increase of the amount of ovarian tissue transplanted. Single embryo replacement resulted in a normal pregnancy and the birth of a healthy child by cesarean section at full-term. No neonatal or maternal postoperative complications occurred. Women facing high-dose pelvic radiotherapy should not be systematically excluded from fertility preservation options, as is currently the trend.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:94 |
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| Enthalten in: |
Acta obstetricia et gynecologica Scandinavica - 94(2015), 3 vom: 06. März, Seite 324-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rodriguez-Wallberg, Kenny A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.04.2015 Date Revised 13.11.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/aogs.12568 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 245 | 1 | 0 | |a Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). | ||
| 520 | |a We report the first successful transplantation of cryopreserved ovarian cortical tissue into heavily irradiated tissues in a patient who had received sterilizing pelvic radiotherapy (54 Gy) and 40 weeks of intensive high-dose chemotherapy for the treatment of Ewing's sarcoma 14 years earlier. Repeated transplantation procedures were required to obtain fully functional follicular development. Enlargement of the transplants over time and increase of the size of the uterus were demonstrated on sequential ultrasonographic examinations. Eggs of good quality that could be fertilized in vitro were obtained only after a substantial incremental increase of the amount of ovarian tissue transplanted. Single embryo replacement resulted in a normal pregnancy and the birth of a healthy child by cesarean section at full-term. No neonatal or maternal postoperative complications occurred. Women facing high-dose pelvic radiotherapy should not be systematically excluded from fertility preservation options, as is currently the trend | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a chemotherapy | |
| 650 | 4 | |a fertility preservation | |
| 650 | 4 | |a iatrogenic ovarian failure | |
| 650 | 4 | |a live birth | |
| 650 | 4 | |a ovarian tissue cryopreservation | |
| 650 | 4 | |a ovarian transplantation | |
| 650 | 4 | |a pregnancy | |
| 650 | 4 | |a survivorship | |
| 650 | 4 | |a uterine irradiation | |
| 700 | 1 | |a Karlström, Per-Olof |e verfasserin |4 aut | |
| 700 | 1 | |a Rezapour, Masoumeh |e verfasserin |4 aut | |
| 700 | 1 | |a Castellanos, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Hreinsson, Julius |e verfasserin |4 aut | |
| 700 | 1 | |a Rasmussen, Carsten |e verfasserin |4 aut | |
| 700 | 1 | |a Sheikhi, Mona |e verfasserin |4 aut | |
| 700 | 1 | |a Ouvrier, Bettina |e verfasserin |4 aut | |
| 700 | 1 | |a Bozóky, Béla |e verfasserin |4 aut | |
| 700 | 1 | |a Olofsson, Jan I |e verfasserin |4 aut | |
| 700 | 1 | |a Lundqvist, Monalill |e verfasserin |4 aut | |
| 700 | 1 | |a Hovatta, Outi |e verfasserin |4 aut | |
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