Fluoroquinolone resistance does not impose a cost on the fitness of Clostridium difficile in vitro
Copyright © 2015, American Society for Microbiology. All Rights Reserved..
Point mutations conferring resistance to fluoroquinolones were introduced in the gyr genes of the reference strain Clostridium difficile 630. Only mutants with the substitution Thr-82→Ile in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested. The absence of a fitness cost in vitro for the most frequent mutations detected in resistant clinical isolates suggests that resistance will be maintained even in the absence of antibiotic pressure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
Antimicrobial agents and chemotherapy - 59(2015), 3 vom: 26. März, Seite 1794-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wasels, François [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 01.12.2015 Date Revised 30.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/AAC.04503-14 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM244828911 |
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| 520 | |a Copyright © 2015, American Society for Microbiology. All Rights Reserved. | ||
| 520 | |a Point mutations conferring resistance to fluoroquinolones were introduced in the gyr genes of the reference strain Clostridium difficile 630. Only mutants with the substitution Thr-82→Ile in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested. The absence of a fitness cost in vitro for the most frequent mutations detected in resistant clinical isolates suggests that resistance will be maintained even in the absence of antibiotic pressure | ||
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| 700 | 1 | |a Barbanti, Fabrizio |e verfasserin |4 aut | |
| 700 | 1 | |a Minton, Nigel P |e verfasserin |4 aut | |
| 700 | 1 | |a Mastrantonio, Paola |e verfasserin |4 aut | |
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