Multimorbidity measures were poor predictors of adverse events in patients aged ≥80 years : a prospective cohort study
Copyright © 2015 Elsevier Inc. All rights reserved..
OBJECTIVES: To assess and compare the ability of two measures of multimorbidity and a simple disease count (DC) to predict health outcomes in a population of patients aged ≥80 years.
STUDY DESIGN AND SETTING: A prospective, observational, and population-based cohort study including 567 individuals [3.0 years (standard deviation ± 0.25) follow-up].
RESULTS: Of the patients, 37.6% were reported with five or more diseases. Multimorbidity was measured by means of a modified Charlson comorbidity index [mCCI; median score, 5 (range, 4-15)], Cumulative Illness Rating Scale [CIRS; median score, 4 (range, 1-11)], and a simple DC of 22 selected chronic conditions [median score, 4 (range, 0-13)]. All measures were independently related to mortality [adjusted hazard ratio (HR) mCCI, 2.5 (confidence interval {CI}: 1.5, 4.1); CIRS, 2.1 (CI: 1.4, 3.2); DC, 2.1 (CI: 1.4, 3.2)] and hospitalization [adjusted HR DC, 2.3 (CI: 1.7, 3.1); mCCI, 2.1 (CI: 1.5, 3.0), CIRS, 1.9 (CI: 1.5, 2.6)] but not to functional decline. Areas under the curve for mortality and hospitalization were all below 0.70. Net reclassification improvements did not indicate that any one measure provided a significant benefit over the others.
CONCLUSION: In this population, the mCCI, CIRS, and unweighted DC predicted mortality and hospitalization but not functional decline. There is no clear advantage of using one measure over another.
| Errataetall: |
CommentIn: J Clin Epidemiol. 2016 Mar;71:114-5. - PMID 26077791 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
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| Enthalten in: |
Journal of clinical epidemiology - 68(2015), 2 vom: 09. Feb., Seite 220-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boeckxstaens, Pauline [VerfasserIn] |
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| Links: |
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| Themen: |
Functional decline |
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| Anmerkungen: |
Date Completed 05.05.2015 Date Revised 02.12.2018 published: Print-Electronic CommentIn: J Clin Epidemiol. 2016 Mar;71:114-5. - PMID 26077791 Citation Status MEDLINE |
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| doi: |
10.1016/j.jclinepi.2014.08.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM244815453 |
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| 500 | |a CommentIn: J Clin Epidemiol. 2016 Mar;71:114-5. - PMID 26077791 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: To assess and compare the ability of two measures of multimorbidity and a simple disease count (DC) to predict health outcomes in a population of patients aged ≥80 years | ||
| 520 | |a STUDY DESIGN AND SETTING: A prospective, observational, and population-based cohort study including 567 individuals [3.0 years (standard deviation ± 0.25) follow-up] | ||
| 520 | |a RESULTS: Of the patients, 37.6% were reported with five or more diseases. Multimorbidity was measured by means of a modified Charlson comorbidity index [mCCI; median score, 5 (range, 4-15)], Cumulative Illness Rating Scale [CIRS; median score, 4 (range, 1-11)], and a simple DC of 22 selected chronic conditions [median score, 4 (range, 0-13)]. All measures were independently related to mortality [adjusted hazard ratio (HR) mCCI, 2.5 (confidence interval {CI}: 1.5, 4.1); CIRS, 2.1 (CI: 1.4, 3.2); DC, 2.1 (CI: 1.4, 3.2)] and hospitalization [adjusted HR DC, 2.3 (CI: 1.7, 3.1); mCCI, 2.1 (CI: 1.5, 3.0), CIRS, 1.9 (CI: 1.5, 2.6)] but not to functional decline. Areas under the curve for mortality and hospitalization were all below 0.70. Net reclassification improvements did not indicate that any one measure provided a significant benefit over the others | ||
| 520 | |a CONCLUSION: In this population, the mCCI, CIRS, and unweighted DC predicted mortality and hospitalization but not functional decline. There is no clear advantage of using one measure over another | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Functional decline | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Measurement | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Multimorbidity | |
| 650 | 4 | |a Older persons | |
| 700 | 1 | |a Vaes, Bert |e verfasserin |4 aut | |
| 700 | 1 | |a Van Pottelbergh, Gijs |e verfasserin |4 aut | |
| 700 | 1 | |a De Sutter, An |e verfasserin |4 aut | |
| 700 | 1 | |a Legrand, Delphine |e verfasserin |4 aut | |
| 700 | 1 | |a Adriaensen, Wim |e verfasserin |4 aut | |
| 700 | 1 | |a Matheï, Catharina |e verfasserin |4 aut | |
| 700 | 1 | |a Dalleur, Olivia |e verfasserin |4 aut | |
| 700 | 1 | |a Degryse, Jan |e verfasserin |4 aut | |
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