Ten-year prognosis in multiple sclerosis : a better outcome in relapsing-remitting patients but not in primary progressive patients
© 2014 EAN..
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) prognosis remains a challenge for both patients and physicians. Complementary to natural history studies, updated population-based data from the first event suggestive of MS, at the time of the first approved disease modifying drug (DMD), are needed. Our objective was to provide a 10-year history of MS from clinical onset at time of first approved DMDs in a population-based cohort.
METHODS: A population-based cohort of patients whose first clinical event suggestive of MS had occurred in Brittany between 2000 and 2001 was prospectively selected. History of relapses, treatments and disability up to 10 years after onset were collected.
RESULTS: In all, 278 patients with either attack-onset (n = 244) or progressive-onset (n = 34) were recruited. Amongst attack-onset patients, 30% remained as clinically isolated syndrome and 70% had a second relapse after a median time of 1.7 years (95% confidence interval 1.2-2.4). 80% of relapsing-remitting MS patients received DMDs for at least 6 months. 29% reached disability status scale (DSS) 3 and 8% DSS 6. Amongst progressive-onset patients, 100% reached DSS 3 and 59% DSS 6.
CONCLUSION(S): Our population-based study reports a lower risk of disability progression at 10-year follow-up in the relapsing-remitting MS group than previously reported. This better prognosis was not observed in the progressive-onset MS group. This finding impacts the prognosis given to patients in clinical practice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
European journal of neurology - 22(2015), 3 vom: 05. März, Seite 507-e35 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kerbrat, A [VerfasserIn] |
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| Links: |
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| Themen: |
Clinically isolated syndrome |
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| Anmerkungen: |
Date Completed 03.12.2015 Date Revised 14.02.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ene.12600 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM244651248 |
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| 245 | 1 | 0 | |a Ten-year prognosis in multiple sclerosis |b a better outcome in relapsing-remitting patients but not in primary progressive patients |
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| 500 | |a Date Completed 03.12.2015 | ||
| 500 | |a Date Revised 14.02.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 EAN. | ||
| 520 | |a BACKGROUND AND PURPOSE: Multiple sclerosis (MS) prognosis remains a challenge for both patients and physicians. Complementary to natural history studies, updated population-based data from the first event suggestive of MS, at the time of the first approved disease modifying drug (DMD), are needed. Our objective was to provide a 10-year history of MS from clinical onset at time of first approved DMDs in a population-based cohort | ||
| 520 | |a METHODS: A population-based cohort of patients whose first clinical event suggestive of MS had occurred in Brittany between 2000 and 2001 was prospectively selected. History of relapses, treatments and disability up to 10 years after onset were collected | ||
| 520 | |a RESULTS: In all, 278 patients with either attack-onset (n = 244) or progressive-onset (n = 34) were recruited. Amongst attack-onset patients, 30% remained as clinically isolated syndrome and 70% had a second relapse after a median time of 1.7 years (95% confidence interval 1.2-2.4). 80% of relapsing-remitting MS patients received DMDs for at least 6 months. 29% reached disability status scale (DSS) 3 and 8% DSS 6. Amongst progressive-onset patients, 100% reached DSS 3 and 59% DSS 6 | ||
| 520 | |a CONCLUSION(S): Our population-based study reports a lower risk of disability progression at 10-year follow-up in the relapsing-remitting MS group than previously reported. This better prognosis was not observed in the progressive-onset MS group. This finding impacts the prognosis given to patients in clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a clinically isolated syndrome | |
| 650 | 4 | |a cohort studies | |
| 650 | 4 | |a demyelinating diseases | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a multiple sclerosis | |
| 650 | 4 | |a prognosis | |
| 700 | 1 | |a Hamonic, S |e verfasserin |4 aut | |
| 700 | 1 | |a Leray, E |e verfasserin |4 aut | |
| 700 | 1 | |a Tron, I |e verfasserin |4 aut | |
| 700 | 1 | |a Edan, G |e verfasserin |4 aut | |
| 700 | 1 | |a Yaouanq, J |e verfasserin |4 aut | |
| 700 | 0 | |a West Neuroscience Network of Excellence (WENNE) |e verfasserin |4 aut | |
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