Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissionsoup.com..
Human immunodeficiency virus (HIV)-infected and viremic individuals exhibit elevated levels of plasma cytokines. Here we show that most cytokines are not in free form but appear associated with exosomes that are distinct from virions. Purified exosomes were analyzed to determine the levels of 21 cytokines and chemokines and compared with exosome-depleted plasma. Most cytokines were markedly enriched in exosomes from HIV-positive individuals relative to negative controls and to plasma. Moreover, exposure of naive peripheral blood mononuclear cells to exosomes purified from HIV-positive patients induced CD38 expression on naive and central memory CD4(+) and CD8(+) T cells, probably contributing to inflammation and viral propagation via bystander cell activation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:211 |
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| Enthalten in: |
The Journal of infectious diseases - 211(2015), 11 vom: 01. Juni, Seite 1712-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Konadu, Kateena Addae [VerfasserIn] |
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| Links: |
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| Themen: |
Chemokines |
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| Anmerkungen: |
Date Completed 20.08.2015 Date Revised 13.11.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiu676 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM244626022 |
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| 520 | |a © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a Human immunodeficiency virus (HIV)-infected and viremic individuals exhibit elevated levels of plasma cytokines. Here we show that most cytokines are not in free form but appear associated with exosomes that are distinct from virions. Purified exosomes were analyzed to determine the levels of 21 cytokines and chemokines and compared with exosome-depleted plasma. Most cytokines were markedly enriched in exosomes from HIV-positive individuals relative to negative controls and to plasma. Moreover, exposure of naive peripheral blood mononuclear cells to exosomes purified from HIV-positive patients induced CD38 expression on naive and central memory CD4(+) and CD8(+) T cells, probably contributing to inflammation and viral propagation via bystander cell activation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a chemokines | |
| 650 | 4 | |a cytokines | |
| 650 | 4 | |a exosomes | |
| 650 | 4 | |a immune activation | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 700 | 1 | |a Chu, Jane |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Ming Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Amancha, Praveen Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Armstrong, Wendy |e verfasserin |4 aut | |
| 700 | 1 | |a Powell, Michael D |e verfasserin |4 aut | |
| 700 | 1 | |a Villinger, Francois |e verfasserin |4 aut | |
| 700 | 1 | |a Bond, Vincent C |e verfasserin |4 aut | |
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