Prenatal head growth and child neuropsychological development at age 14 months
Copyright © 2015 Elsevier Inc. All rights reserved..
OBJECTIVE: We sought to assess the association between prenatal head growth and child neuropsychological development in the general population.
STUDY DESIGN: We evaluated 2104 children at the age of 14 months from a population-based birth cohort in Spain. Head circumference (HC) was measured by ultrasound examinations at weeks 12, 20, and 34 of gestation and by a nurse at birth. Head growth was assessed using conditional SD scores between weeks 12-20 and 20-34. Trained psychologists assessed neuropsychological functioning using the Bayley Scales of Infant Development. Head size measurements at birth were transformed into a 3-category variable: microcephalic (<10th percentile), normocephalic (≥10th and <90th percentile), and macrocephalic (≥90th percentile) based on the cohort distribution. P values<.05 were considered statistically significant.
RESULTS: No overall associations were observed between HC or head growth and mental and psychomotor scores. In particular, no associations were found between HC at birth and mental scores (coefficient, 0.04; 95% confidence interval, -0.02 to 0.09) and between interval head growth (20-34 weeks) and mental scores (0.31; 95% confidence interval, -0.36 to 0.99). Upon stratification by microcephalic, normocephalic, or macrocephalic head size, results were imprecise, although there were some significant associations in the microcephalic and macrocephalic groups. Adjustment by various child and maternal cofactors did not affect results. The minimum sample size required for present study was 883 patients (β=2, α=0.05, power=0.80).
CONCLUSION: Overall prenatal and perinatal HC was not associated with 14-month-old neuropsychological development. Findings suggest HC growth during uterine life among healthy infants may not be an important marker of early-life neurodevelopment but may be marginally useful with specific populations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:212 |
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| Enthalten in: |
American journal of obstetrics and gynecology - 212(2015), 5 vom: 14. Mai, Seite 661.e1-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Álamo-Junquera, Dolores [VerfasserIn] |
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| Links: |
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| Themen: |
Cognitive functions |
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| Anmerkungen: |
Date Completed 27.07.2015 Date Revised 25.11.2016 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ajog.2014.12.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM244516456 |
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| 245 | 1 | 0 | |a Prenatal head growth and child neuropsychological development at age 14 months |
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| 500 | |a Date Revised 25.11.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: We sought to assess the association between prenatal head growth and child neuropsychological development in the general population | ||
| 520 | |a STUDY DESIGN: We evaluated 2104 children at the age of 14 months from a population-based birth cohort in Spain. Head circumference (HC) was measured by ultrasound examinations at weeks 12, 20, and 34 of gestation and by a nurse at birth. Head growth was assessed using conditional SD scores between weeks 12-20 and 20-34. Trained psychologists assessed neuropsychological functioning using the Bayley Scales of Infant Development. Head size measurements at birth were transformed into a 3-category variable: microcephalic (<10th percentile), normocephalic (≥10th and <90th percentile), and macrocephalic (≥90th percentile) based on the cohort distribution. P values<.05 were considered statistically significant | ||
| 520 | |a RESULTS: No overall associations were observed between HC or head growth and mental and psychomotor scores. In particular, no associations were found between HC at birth and mental scores (coefficient, 0.04; 95% confidence interval, -0.02 to 0.09) and between interval head growth (20-34 weeks) and mental scores (0.31; 95% confidence interval, -0.36 to 0.99). Upon stratification by microcephalic, normocephalic, or macrocephalic head size, results were imprecise, although there were some significant associations in the microcephalic and macrocephalic groups. Adjustment by various child and maternal cofactors did not affect results. The minimum sample size required for present study was 883 patients (β=2, α=0.05, power=0.80) | ||
| 520 | |a CONCLUSION: Overall prenatal and perinatal HC was not associated with 14-month-old neuropsychological development. Findings suggest HC growth during uterine life among healthy infants may not be an important marker of early-life neurodevelopment but may be marginally useful with specific populations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a cognitive functions | |
| 650 | 4 | |a head circumference | |
| 650 | 4 | |a neurodevelopment | |
| 650 | 4 | |a neuropsychological development | |
| 650 | 4 | |a population-based study | |
| 650 | 4 | |a prenatal growth | |
| 700 | 1 | |a Sunyer, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Iñiguez, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Ballester, Ferran |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Esteban, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Forns, Joan |e verfasserin |4 aut | |
| 700 | 1 | |a Turner, Michelle C |e verfasserin |4 aut | |
| 700 | 1 | |a Lertxundi, Aitana |e verfasserin |4 aut | |
| 700 | 1 | |a Lertxundi, Nerea |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez-Somoano, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez-Dehli, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Julvez, Jordi |e verfasserin |4 aut | |
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