USP11 regulates p53 stability by deubiquitinating p53
The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppressor function, which is tightly controlled by ubiquitin-dependent degradation primarily through its negative regulator murine double minute 2 (Mdm2). To better understand the regulation of p53, we tested the interaction between p53 and USP11 using co-immunoprecipitation. The results show that USP11, an ubiquitin-specific protease, forms specific complexes with p53 and stabilizes p53 by deubiquitinating it. Moreover, down-regulation of USP11 dramatically attenuated p53 induction in response to DNA damage stress. These findings reveal that USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Journal of Zhejiang University. Science. B - 15(2014), 12 vom: 04. Dez., Seite 1032-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ke, Jia-ying [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 18.08.2015 Date Revised 02.04.2019 published: Print Citation Status MEDLINE |
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| doi: |
10.1631/jzus.B1400180 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM244256551 |
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| 245 | 1 | 0 | |a USP11 regulates p53 stability by deubiquitinating p53 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppressor function, which is tightly controlled by ubiquitin-dependent degradation primarily through its negative regulator murine double minute 2 (Mdm2). To better understand the regulation of p53, we tested the interaction between p53 and USP11 using co-immunoprecipitation. The results show that USP11, an ubiquitin-specific protease, forms specific complexes with p53 and stabilizes p53 by deubiquitinating it. Moreover, down-regulation of USP11 dramatically attenuated p53 induction in response to DNA damage stress. These findings reveal that USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Deubiquitination | |
| 650 | 4 | |a Stability | |
| 650 | 4 | |a USP11 | |
| 650 | 4 | |a p53 | |
| 650 | 7 | |a TP53 protein, human |2 NLM | |
| 650 | 7 | |a Tumor Suppressor Protein p53 |2 NLM | |
| 650 | 7 | |a USP11 protein, human |2 NLM | |
| 650 | 7 | |a Ubiquitin |2 NLM | |
| 650 | 7 | |a Cycloheximide |2 NLM | |
| 650 | 7 | |a 98600C0908 |2 NLM | |
| 650 | 7 | |a MDM2 protein, human |2 NLM | |
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| 700 | 1 | |a Dai, Cong-jie |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wen-lin |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Jin-hua |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Ai-juan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Guang-ping |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Kao-sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Chun-lin |e verfasserin |4 aut | |
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