False positive dexamethasone suppression test in a patient being treated with carbamazepine
We present a case story of a patient suspected having Cushing's syndrome (CS), with spuriously elevated P-cortisol level diagnosed by overnight and two days dexamethasone suppression test (DST). The patient was being treated with carbamazepine, and after two weeks withdrawal from this drug, both two-day DST and urinary free cortisol showed normal results. There are many pitfalls in the process of diagnosing CS. Several conditions mimic the disease and others cause hypercortisolism. Liver and kidney failure as well as several drugs can influence the test results. It is important to bare this in mind during the diagnostic work-up of suspected CS.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2014 |
|---|---|
| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:176 |
|---|---|
| Enthalten in: |
Ugeskrift for laeger - 176(2014), 3A vom: 13. Jan., Seite V04130254 |
| Sprache: |
Dänisch |
|---|
| Weiterer Titel: |
Falsk positiv dexamethasonsuppressionstest hos en patient i behandling med carbamazepine |
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| Beteiligte Personen: |
Iversen, Ane Bull [VerfasserIn] |
|---|
| Themen: |
33CM23913M |
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| Anmerkungen: |
Date Completed 20.07.2016 Date Revised 25.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM243077009 |
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| 520 | |a We present a case story of a patient suspected having Cushing's syndrome (CS), with spuriously elevated P-cortisol level diagnosed by overnight and two days dexamethasone suppression test (DST). The patient was being treated with carbamazepine, and after two weeks withdrawal from this drug, both two-day DST and urinary free cortisol showed normal results. There are many pitfalls in the process of diagnosing CS. Several conditions mimic the disease and others cause hypercortisolism. Liver and kidney failure as well as several drugs can influence the test results. It is important to bare this in mind during the diagnostic work-up of suspected CS | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Analgesics, Non-Narcotic |2 NLM | |
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| 700 | 1 | |a Poulsen, Per Løgstrup |e verfasserin |4 aut | |
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