The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance
Mutations in HIV-1 reverse transcriptase (RT) that confer nucleoside analog RT inhibitor resistance have highlighted the functional importance of several active site residues (M184, Q151 and K65) in RT catalytic function. Of these, K65 residue is notable due to its pivotal position in the dNTP-binding pocket, its involvement in nucleoside analog resistance and polymerase fidelity. This review focuses on K65 residue and summarizes a substantial body of biochemical and structural studies of its role in RT function and the functional consequences of the K65R mutation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
Viruses - 6(2014), 10 vom: 23. Okt., Seite 4080-94 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Garforth, Scott J [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.03.2017 Date Revised 13.11.2018 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/v6104080 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM24302455X |
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| 245 | 1 | 4 | |a The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Mutations in HIV-1 reverse transcriptase (RT) that confer nucleoside analog RT inhibitor resistance have highlighted the functional importance of several active site residues (M184, Q151 and K65) in RT catalytic function. Of these, K65 residue is notable due to its pivotal position in the dNTP-binding pocket, its involvement in nucleoside analog resistance and polymerase fidelity. This review focuses on K65 residue and summarizes a substantial body of biochemical and structural studies of its role in RT function and the functional consequences of the K65R mutation | ||
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