Herpes simplex infection and the risk of Alzheimer's disease : A nested case-control study
Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Herpes simplex virus (HSV) is thought to play an etiological role in the development of Alzheimer's disease (AD).
METHODS: Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years) and 360 age- and sex-matched dementia-free controls, taken on average 9.6 years before AD diagnosis, were analyzed for anti-HSV antibodies (immunoglobulin G, IgG, and immunoglobulin M, IgM) by enzyme-linked immunosorbent assays.
RESULTS: In the complete sample group, the presence of anti-HSV IgG and IgM antibodies did not increase the risk of AD significantly (odds ratio (OR) 1.636, P = .069 and OR 1.368, P = .299, respectively). In cases with 6.6 years or more between plasma sampling and AD diagnosis (n = 270), there was a significant association between presence of anti-HSV IgG antibodies and AD (OR 2.250, P = .019).
CONCLUSION: Among persons with a follow-up time of 6.6 years or more, HSV infection was significantly associated with AD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Alzheimer's & dementia : the journal of the Alzheimer's Association - 11(2015), 6 vom: 01. Juni, Seite 587-92 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lövheim, Hugo [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Alzheimer's disease |
|---|
| Anmerkungen: |
Date Completed 02.03.2016 Date Revised 15.06.2015 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jalz.2014.07.157 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM242684262 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM242684262 | ||
| 003 | DE-627 | ||
| 005 | 20231224130930.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jalz.2014.07.157 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0809.xml |
| 035 | |a (DE-627)NLM242684262 | ||
| 035 | |a (NLM)25304990 | ||
| 035 | |a (PII)S1552-5260(14)02770-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lövheim, Hugo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Herpes simplex infection and the risk of Alzheimer's disease |b A nested case-control study |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.03.2016 | ||
| 500 | |a Date Revised 15.06.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Herpes simplex virus (HSV) is thought to play an etiological role in the development of Alzheimer's disease (AD) | ||
| 520 | |a METHODS: Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years) and 360 age- and sex-matched dementia-free controls, taken on average 9.6 years before AD diagnosis, were analyzed for anti-HSV antibodies (immunoglobulin G, IgG, and immunoglobulin M, IgM) by enzyme-linked immunosorbent assays | ||
| 520 | |a RESULTS: In the complete sample group, the presence of anti-HSV IgG and IgM antibodies did not increase the risk of AD significantly (odds ratio (OR) 1.636, P = .069 and OR 1.368, P = .299, respectively). In cases with 6.6 years or more between plasma sampling and AD diagnosis (n = 270), there was a significant association between presence of anti-HSV IgG antibodies and AD (OR 2.250, P = .019) | ||
| 520 | |a CONCLUSION: Among persons with a follow-up time of 6.6 years or more, HSV infection was significantly associated with AD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a Dementia | |
| 650 | 4 | |a HSV | |
| 650 | 4 | |a Herpes | |
| 650 | 4 | |a Herpes simplex | |
| 650 | 4 | |a Nested case-control study | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
| 650 | 7 | |a Immunoglobulin G |2 NLM | |
| 650 | 7 | |a Immunoglobulin M |2 NLM | |
| 700 | 1 | |a Gilthorpe, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Johansson, Anders |e verfasserin |4 aut | |
| 700 | 1 | |a Eriksson, Sture |e verfasserin |4 aut | |
| 700 | 1 | |a Hallmans, Göran |e verfasserin |4 aut | |
| 700 | 1 | |a Elgh, Fredrik |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Alzheimer's & dementia : the journal of the Alzheimer's Association |d 2005 |g 11(2015), 6 vom: 01. Juni, Seite 587-92 |w (DE-627)NLM168942356 |x 1552-5279 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2015 |g number:6 |g day:01 |g month:06 |g pages:587-92 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jalz.2014.07.157 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2015 |e 6 |b 01 |c 06 |h 587-92 | ||