Synthesis and antiviral activities of some 2,4,6-trisubstituted 1,3,5-triazines
We describe the synthesis and results of biological evaluation of newly designed 2,4,6-trisubstituted symmetrical 1,3,5-triazine (TAZ) derivatives. Among the tested trisubstituted TAZ derivatives, some CS-symmetrical alkoxy-amino-substituted TAZ derivatives, including 7ggp and 6dpp, showed significant antiviral activity against herpes simplex virus type 1 (HSV-1). The compound with the highest level of antiviral activity was C3-symmetrical trialkoxy-TAZ derivative 4bbb, which showed a considerably high selectivity index (IC50/EC50=256.6). The structure-activity relationships for anti-HSV-1 activity of the tested 2,4,6-trisubstituted TAZ derivatives are also described.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Chemical & pharmaceutical bulletin - 62(2014), 10 vom: 01., Seite 1032-40 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mibu, Nobuko [VerfasserIn] |
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| Themen: |
5U4L4QHD6I |
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| Anmerkungen: |
Date Completed 05.06.2015 Date Revised 10.12.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM242386873 |
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| 100 | 1 | |a Mibu, Nobuko |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis and antiviral activities of some 2,4,6-trisubstituted 1,3,5-triazines |
| 264 | 1 | |c 2014 | |
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| 500 | |a Date Completed 05.06.2015 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We describe the synthesis and results of biological evaluation of newly designed 2,4,6-trisubstituted symmetrical 1,3,5-triazine (TAZ) derivatives. Among the tested trisubstituted TAZ derivatives, some CS-symmetrical alkoxy-amino-substituted TAZ derivatives, including 7ggp and 6dpp, showed significant antiviral activity against herpes simplex virus type 1 (HSV-1). The compound with the highest level of antiviral activity was C3-symmetrical trialkoxy-TAZ derivative 4bbb, which showed a considerably high selectivity index (IC50/EC50=256.6). The structure-activity relationships for anti-HSV-1 activity of the tested 2,4,6-trisubstituted TAZ derivatives are also described | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
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| 700 | 1 | |a Yokomizo, Kazumi |e verfasserin |4 aut | |
| 700 | 1 | |a Koga, Airi |e verfasserin |4 aut | |
| 700 | 1 | |a Honda, Miyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Mizokami, Kou |e verfasserin |4 aut | |
| 700 | 1 | |a Fujii, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ota, Norimasa |e verfasserin |4 aut | |
| 700 | 1 | |a Yuzuriha, Ai |e verfasserin |4 aut | |
| 700 | 1 | |a Ishimaru, Kanji |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Jianrong |e verfasserin |4 aut | |
| 700 | 1 | |a Miyata, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Sumoto, Kunihiro |e verfasserin |4 aut | |
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