Evaluation of the recrystallization kinetics of hot-melt extruded polymeric solid dispersions using an improved Avrami equation
The recrystallization of an amorphous drug in a solid dispersion system could lead to a loss in the drug solubility and bioavailability. The primary objective of the current research was to use an improved kinetic model to evaluate the recrystallization kinetics of amorphous structures and to further understand the factors influencing the physical stability of amorphous solid dispersions. Amorphous solid dispersions of fenofibrate with different molecular weights of hydroxypropylcellulose, HPC (Klucel™ LF, EF, ELF) were prepared utilizing hot-melt extrusion technology. Differential scanning calorimetry was utilized to quantitatively analyze the extent of recrystallization in the samples stored at different temperatures and relative humidity (RH) conditions. The experimental data were fitted into the improved kinetics model of a modified Avrami equation to calculate the recrystallization rate constants. Klucel LF, the largest molecular weight among the HPCs used, demonstrated the greatest inhibition of fenofibrate recrystallization. Additionally, the recrystallization rate (k) decreased with increasing polymer content, however exponentially increased with higher temperature. Also k increased linearly rather than exponentially over the range of RH studied.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Drug development and industrial pharmacy - 41(2015), 9 vom: 15., Seite 1479-87 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Feng, Xin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.06.2016 Date Revised 21.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3109/03639045.2014.958755 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM24193172X |
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| 100 | 1 | |a Feng, Xin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of the recrystallization kinetics of hot-melt extruded polymeric solid dispersions using an improved Avrami equation |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 01.06.2016 | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The recrystallization of an amorphous drug in a solid dispersion system could lead to a loss in the drug solubility and bioavailability. The primary objective of the current research was to use an improved kinetic model to evaluate the recrystallization kinetics of amorphous structures and to further understand the factors influencing the physical stability of amorphous solid dispersions. Amorphous solid dispersions of fenofibrate with different molecular weights of hydroxypropylcellulose, HPC (Klucel™ LF, EF, ELF) were prepared utilizing hot-melt extrusion technology. Differential scanning calorimetry was utilized to quantitatively analyze the extent of recrystallization in the samples stored at different temperatures and relative humidity (RH) conditions. The experimental data were fitted into the improved kinetics model of a modified Avrami equation to calculate the recrystallization rate constants. Klucel LF, the largest molecular weight among the HPCs used, demonstrated the greatest inhibition of fenofibrate recrystallization. Additionally, the recrystallization rate (k) decreased with increasing polymer content, however exponentially increased with higher temperature. Also k increased linearly rather than exponentially over the range of RH studied | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Avrami equation | |
| 650 | 4 | |a hot-melt extrusion | |
| 650 | 4 | |a kinetics model | |
| 650 | 4 | |a physical stability | |
| 650 | 4 | |a recrystallization | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Cellulose |2 NLM | |
| 650 | 7 | |a 9004-34-6 |2 NLM | |
| 650 | 7 | |a hydroxypropylcellulose |2 NLM | |
| 650 | 7 | |a 9XZ8H6N6OH |2 NLM | |
| 650 | 7 | |a Fenofibrate |2 NLM | |
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| 700 | 1 | |a Ye, Xingyou |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Jun-Bom |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Wenli |e verfasserin |4 aut | |
| 700 | 1 | |a Morott, Joe |e verfasserin |4 aut | |
| 700 | 1 | |a Beissner, Brad |e verfasserin |4 aut | |
| 700 | 1 | |a Lian, Zhuoyang John |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto, Elanor |e verfasserin |4 aut | |
| 700 | 1 | |a Bi, Vivian |e verfasserin |4 aut | |
| 700 | 1 | |a Porter, Stu |e verfasserin |4 aut | |
| 700 | 1 | |a Durig, Tom |e verfasserin |4 aut | |
| 700 | 1 | |a Majumdar, Soumyajit |e verfasserin |4 aut | |
| 700 | 1 | |a Repka, Michael A |e verfasserin |4 aut | |
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