Effect of nicotine on melanogenesis and antioxidant status in HEMn-LP melanocytes
Copyright © 2014 Elsevier Inc. All rights reserved..
Nicotine is a natural ingredient of tobacco plants and is responsible for the addictive properties of tobacco. Nowadays nicotine is also commonly used as a form of smoking cessation therapy. It is suggested that nicotine may be accumulated in human tissues containing melanin. This may in turn affect biochemical processes in human cells producing melanin. The aim of this study was to examine the effect of nicotine on melanogenesis and antioxidant status in cultured normal human melanocytes HEMn-LP. Nicotine induced concentration-dependent loss in melanocytes viability. The value of EC50 was determined to be 7.43 mM. Nicotine inhibited a melanization process in human light pigmented melanocytes and caused alterations of antioxidant defense system. Significant changes in cellular antioxidant enzymes: superoxide dismutase and catalase activities and in hydrogen peroxide content were stated. The obtained results may explain a potential influence of nicotine on biochemical processes in melanocytes in vivo during long term exposition to nicotine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:134 |
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| Enthalten in: |
Environmental research - 134(2014) vom: 05. Okt., Seite 309-14 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Delijewski, Marcin [VerfasserIn] |
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| Links: |
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| Themen: |
6M3C89ZY6R |
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| Anmerkungen: |
Date Completed 03.02.2015 Date Revised 19.11.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.envres.2014.08.015 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier Inc. All rights reserved. | ||
| 520 | |a Nicotine is a natural ingredient of tobacco plants and is responsible for the addictive properties of tobacco. Nowadays nicotine is also commonly used as a form of smoking cessation therapy. It is suggested that nicotine may be accumulated in human tissues containing melanin. This may in turn affect biochemical processes in human cells producing melanin. The aim of this study was to examine the effect of nicotine on melanogenesis and antioxidant status in cultured normal human melanocytes HEMn-LP. Nicotine induced concentration-dependent loss in melanocytes viability. The value of EC50 was determined to be 7.43 mM. Nicotine inhibited a melanization process in human light pigmented melanocytes and caused alterations of antioxidant defense system. Significant changes in cellular antioxidant enzymes: superoxide dismutase and catalase activities and in hydrogen peroxide content were stated. The obtained results may explain a potential influence of nicotine on biochemical processes in melanocytes in vivo during long term exposition to nicotine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Antioxidant enzymes | |
| 650 | 4 | |a Melanin | |
| 650 | 4 | |a Melanocytes | |
| 650 | 4 | |a Nicotine | |
| 650 | 4 | |a Tyrosinase | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Melanins |2 NLM | |
| 650 | 7 | |a Nicotine |2 NLM | |
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| 700 | 1 | |a Beberok, Artur |e verfasserin |4 aut | |
| 700 | 1 | |a Otręba, Michał |e verfasserin |4 aut | |
| 700 | 1 | |a Wrześniok, Dorota |e verfasserin |4 aut | |
| 700 | 1 | |a Rok, Jakub |e verfasserin |4 aut | |
| 700 | 1 | |a Buszman, Ewa |e verfasserin |4 aut | |
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