Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome
Copyright © 2014 Elsevier Inc. All rights reserved..
Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:155 |
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| Enthalten in: |
Clinical immunology (Orlando, Fla.) - 155(2014), 1 vom: 12. Nov., Seite 42-46 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shen, Long [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-La; |
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| Anmerkungen: |
Date Completed 26.01.2015 Date Revised 31.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clim.2014.08.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM241501962 |
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| 245 | 1 | 0 | |a Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome |
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| 500 | |a Date Revised 31.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier Inc. All rights reserved. | ||
| 520 | |a Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-La; | |
| 650 | 4 | |a Anti-Ro; | |
| 650 | 4 | |a Anti-salivary gland protein 1 (SP1) | |
| 650 | 4 | |a Rheumatoid arthritis; | |
| 650 | 4 | |a Sjogren's syndrome; | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a Salivary Proteins and Peptides |2 NLM | |
| 700 | 1 | |a Kapsogeorgou, Efstathia K |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Meixing |e verfasserin |4 aut | |
| 700 | 1 | |a Suresh, Lakshmanan |e verfasserin |4 aut | |
| 700 | 1 | |a Malyavantham, Kishore |e verfasserin |4 aut | |
| 700 | 1 | |a Tzioufas, Anthanasios G |e verfasserin |4 aut | |
| 700 | 1 | |a Ambrus, Julian L |c Jr |e verfasserin |4 aut | |
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