Dysfunction of thermoregulation contributes to the generation of hyperthermia-induced seizures
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved..
Febrile seizures (FS) are generally defined as seizures taking place during fever. Long-term prognosis, including development of epilepsy and malformation of cognitive function, has been demonstrated after infantile FS. However, the mechanism that triggers seizures in hyperthermic environment is still unclear. We here found that the body temperature of rat pups that experienced experimental FS was markedly decreased (∼28°C) after they were removed from the hyperthermic environment. Both the seizure generation and the temperature drop after seizure attack were abolished by either pre-treatment with chlorpromazine (CPZ), which impairs the thermoregulation, or by an electrolytic lesion of the preoptic area and anterior hypothalamus (PO/AH). However, the non-steroidal anti-inflammatory drug celecoxib did not affect the seizure incidence and the decrease in body temperature after seizure attack. In addition, pentobarbital prevented the generation of seizures, but did not reverse the decrease of body temperature after FS. Therefore, our work indicates that an over-regulation of body temperature occurs during hyperthermic environment, and that the dysfunction of thermoregulation in the PO/AH following hyperthermia contributes to the generation of FS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:581 |
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| Enthalten in: |
Neuroscience letters - 581(2014) vom: 03. Okt., Seite 129-34 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Feng, Bo [VerfasserIn] |
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| Links: |
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| Themen: |
Anticonvulsants |
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| Anmerkungen: |
Date Completed 09.06.2015 Date Revised 16.09.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2014.08.037 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM241443083 |
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| 245 | 1 | 0 | |a Dysfunction of thermoregulation contributes to the generation of hyperthermia-induced seizures |
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| 520 | |a Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. | ||
| 520 | |a Febrile seizures (FS) are generally defined as seizures taking place during fever. Long-term prognosis, including development of epilepsy and malformation of cognitive function, has been demonstrated after infantile FS. However, the mechanism that triggers seizures in hyperthermic environment is still unclear. We here found that the body temperature of rat pups that experienced experimental FS was markedly decreased (∼28°C) after they were removed from the hyperthermic environment. Both the seizure generation and the temperature drop after seizure attack were abolished by either pre-treatment with chlorpromazine (CPZ), which impairs the thermoregulation, or by an electrolytic lesion of the preoptic area and anterior hypothalamus (PO/AH). However, the non-steroidal anti-inflammatory drug celecoxib did not affect the seizure incidence and the decrease in body temperature after seizure attack. In addition, pentobarbital prevented the generation of seizures, but did not reverse the decrease of body temperature after FS. Therefore, our work indicates that an over-regulation of body temperature occurs during hyperthermic environment, and that the dysfunction of thermoregulation in the PO/AH following hyperthermia contributes to the generation of FS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Body temperature | |
| 650 | 4 | |a Febrile seizure | |
| 650 | 4 | |a Hyperthermia | |
| 650 | 4 | |a PO/AH | |
| 650 | 4 | |a Thermoregulation | |
| 650 | 7 | |a Anticonvulsants |2 NLM | |
| 650 | 7 | |a Pentobarbital |2 NLM | |
| 650 | 7 | |a I4744080IR |2 NLM | |
| 650 | 7 | |a Chlorpromazine |2 NLM | |
| 650 | 7 | |a U42B7VYA4P |2 NLM | |
| 700 | 1 | |a Tang, Yang-Shun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Yun-Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Ceng-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Zheng-Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiang-Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shi-Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Wei-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhong |e verfasserin |4 aut | |
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