Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke : a systematic review and meta-analysis
Copyright © 2014 Elsevier B.V. All rights reserved..
We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:274 |
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| Enthalten in: |
Journal of neuroimmunology - 274(2014), 1-2 vom: 15. Sept., Seite 215-24 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bustamante, Alejandro [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.11.2014 Date Revised 30.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jneuroim.2014.07.015 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM240693108 |
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| 100 | 1 | |a Bustamante, Alejandro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke |b a systematic review and meta-analysis |
| 264 | 1 | |c 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 30.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier B.V. All rights reserved. | ||
| 520 | |a We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Individual participant data analysis | |
| 650 | 4 | |a Interleukin-6 | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Outcome | |
| 650 | 4 | |a Post-stroke infection | |
| 650 | 4 | |a Stroke | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a IL6 protein, human |2 NLM | |
| 650 | 7 | |a Interleukin-6 |2 NLM | |
| 700 | 1 | |a Sobrino, Tomás |e verfasserin |4 aut | |
| 700 | 1 | |a Giralt, Dolors |e verfasserin |4 aut | |
| 700 | 1 | |a García-Berrocoso, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Llombart, Victor |e verfasserin |4 aut | |
| 700 | 1 | |a Ugarriza, Iratxe |e verfasserin |4 aut | |
| 700 | 1 | |a Espadaler, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez, Noelia |e verfasserin |4 aut | |
| 700 | 1 | |a Sudlow, Cathie |e verfasserin |4 aut | |
| 700 | 1 | |a Castellanos, Mar |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Craig J |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Yánez, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Waje-Andreassen, Ulrike |e verfasserin |4 aut | |
| 700 | 1 | |a Tanne, David |e verfasserin |4 aut | |
| 700 | 1 | |a Oto, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Barber, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Worthmann, Hans |e verfasserin |4 aut | |
| 700 | 1 | |a Wartenberg, Katja E |e verfasserin |4 aut | |
| 700 | 1 | |a Becker, Kyra J |e verfasserin |4 aut | |
| 700 | 1 | |a Chakraborty, Baidarbhi |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Seung-Hun |e verfasserin |4 aut | |
| 700 | 1 | |a Whiteley, William N |e verfasserin |4 aut | |
| 700 | 1 | |a Castillo, José |e verfasserin |4 aut | |
| 700 | 1 | |a Montaner, Joan |e verfasserin |4 aut | |
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