Complications in the first 5 years following cataract surgery in infants with and without intraocular lens implantation in the Infant Aphakia Treatment Study
Copyright © 2014 Elsevier Inc. All rights reserved..
PURPOSE: To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implantation.
DESIGN: Prospective randomized clinical trial.
METHODS: A total of 114 infants were enrolled in the Infant Aphakia Treatment Study, a randomized, multi-center (12) clinical trial comparing the treatment of unilateral aphakia in patients under 7 months of age with a primary IOL implant or contact lens. The rate, character, and severity of intraoperative complications, adverse events, and additional intraocular surgeries during the first 5 postoperative years in the 2 groups were examined.
RESULTS: There were more patients with intraoperative complications (28% vs 11%, P = .031), adverse events (81% vs 56%, P = .008), and more additional intraocular surgeries (72% vs 16%, P < .0001) in the IOL group than in the contact lens group. However, the number of patients with adverse events in the contact lens group increased (15 to 24) in postoperative years 2-5 compared to the first postoperative year, while it decreased (44 to 14) in years 2-5 compared to the first postoperative year in the IOL group. If only one half of the patients in the contact lens (aphakic) group eventually undergo secondary IOL implantation, the number of additional intraocular surgeries in the 2 groups will be approximately equal.
CONCLUSION: The increased rate of complications, adverse events, and additional intraocular surgeries associated with IOL implantation in infants <7 months of age militates toward leaving babies aphakic if it is considered likely that the family will be successful with contact lens correction.
| Errataetall: |
CommentIn: Am J Ophthalmol. 2014 Dec;158(6):1360-1. - PMID 25457712 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:158 |
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| Enthalten in: |
American journal of ophthalmology - 158(2014), 5 vom: 30. Nov., Seite 892-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Plager, David A [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 27.01.2015 Date Revised 09.04.2022 published: Print-Electronic ClinicalTrials.gov: NCT00212134 CommentIn: Am J Ophthalmol. 2014 Dec;158(6):1360-1. - PMID 25457712 Citation Status MEDLINE |
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| doi: |
10.1016/j.ajo.2014.07.031 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM240563522 |
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| 100 | 1 | |a Plager, David A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Complications in the first 5 years following cataract surgery in infants with and without intraocular lens implantation in the Infant Aphakia Treatment Study |
| 264 | 1 | |c 2014 | |
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| 500 | |a Date Completed 27.01.2015 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT00212134 | ||
| 500 | |a CommentIn: Am J Ophthalmol. 2014 Dec;158(6):1360-1. - PMID 25457712 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implantation | ||
| 520 | |a DESIGN: Prospective randomized clinical trial | ||
| 520 | |a METHODS: A total of 114 infants were enrolled in the Infant Aphakia Treatment Study, a randomized, multi-center (12) clinical trial comparing the treatment of unilateral aphakia in patients under 7 months of age with a primary IOL implant or contact lens. The rate, character, and severity of intraoperative complications, adverse events, and additional intraocular surgeries during the first 5 postoperative years in the 2 groups were examined | ||
| 520 | |a RESULTS: There were more patients with intraoperative complications (28% vs 11%, P = .031), adverse events (81% vs 56%, P = .008), and more additional intraocular surgeries (72% vs 16%, P < .0001) in the IOL group than in the contact lens group. However, the number of patients with adverse events in the contact lens group increased (15 to 24) in postoperative years 2-5 compared to the first postoperative year, while it decreased (44 to 14) in years 2-5 compared to the first postoperative year in the IOL group. If only one half of the patients in the contact lens (aphakic) group eventually undergo secondary IOL implantation, the number of additional intraocular surgeries in the 2 groups will be approximately equal | ||
| 520 | |a CONCLUSION: The increased rate of complications, adverse events, and additional intraocular surgeries associated with IOL implantation in infants <7 months of age militates toward leaving babies aphakic if it is considered likely that the family will be successful with contact lens correction | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Lynn, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Buckley, Edward G |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, M Edward |e verfasserin |4 aut | |
| 700 | 1 | |a Lambert, Scott R |e verfasserin |4 aut | |
| 700 | 0 | |a Infant Aphakia Treatment Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Plager, David A |e investigator |4 oth | |
| 700 | 1 | |a Lynn, Michael J |e investigator |4 oth | |
| 700 | 1 | |a Buckley, Edward G |e investigator |4 oth | |
| 700 | 1 | |a Wilson, M Edward |e investigator |4 oth | |
| 700 | 1 | |a Lambert, Scott R |e investigator |4 oth | |
| 700 | 1 | |a Lambert, Scott R |e investigator |4 oth | |
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| 700 | 1 | |a Wilson, M Edward |e investigator |4 oth | |
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| 700 | 1 | |a Drews-Botsch, Carolyn |e investigator |4 oth | |
| 700 | 1 | |a Hartmann, E Eugenie |e investigator |4 oth | |
| 700 | 1 | |a Everett, Donald F |e investigator |4 oth | |
| 700 | 1 | |a Russell, Buddy |e investigator |4 oth | |
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