Immunopharmacological modulation of mast cells
Copyright © 2014 Elsevier Ltd. All rights reserved..
Mast cells produce a wide spectrum of mediators and they have been implicated in several physiopathological conditions (e.g. allergic reactions and certain tumors). Pharmacologic agents that modulate the release of mediators from mast cells has helped to elucidate the biochemical mechanisms by which immunological and non-immunological stimuli activate these cells. Furthermore, the study of surface receptors and signaling pathways associated with mast cell activation revealed novel pharmacologic targets. Thus, the development of pharmacologic agents based on this new wave of knowledge holds promise for the treatment of several mast cell-mediated disorders.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Current opinion in pharmacology - 17(2014) vom: 01. Aug., Seite 45-57 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Borriello, Francesco [VerfasserIn] |
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| Links: |
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| Themen: |
Immunologic Factors |
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| Anmerkungen: |
Date Completed 10.06.2015 Date Revised 07.10.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.coph.2014.07.002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Mast cells produce a wide spectrum of mediators and they have been implicated in several physiopathological conditions (e.g. allergic reactions and certain tumors). Pharmacologic agents that modulate the release of mediators from mast cells has helped to elucidate the biochemical mechanisms by which immunological and non-immunological stimuli activate these cells. Furthermore, the study of surface receptors and signaling pathways associated with mast cell activation revealed novel pharmacologic targets. Thus, the development of pharmacologic agents based on this new wave of knowledge holds promise for the treatment of several mast cell-mediated disorders | ||
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| 700 | 1 | |a Marone, Gianni |e verfasserin |4 aut | |
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