Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans
Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implication of FTO in fetal growth, we measured its placental expression in samples including extremes of abnormal fetal growth, such as after intrauterine growth restriction (IUGR) or macrosomia in both rats and humans. In rats, fetal growth was modulated by maternal nutritional modifications. In humans, placental villi were collected from pathological pregnancies (i.e. with IUGR or fetal macrosomia). Placental FTO mRNA expression was reduced by IUGR but was not significantly affected by macrosomia in either rats or humans. Our data suggest that placental FTO may participate in interactions between the in utero environment and the control of fetal growth under IUGR conditions by modulating epigenetic processes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2013 |
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| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
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| Enthalten in: |
Journal of developmental origins of health and disease - 4(2013), 2 vom: 06. Apr., Seite 134-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mayeur, S [VerfasserIn] |
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| Anmerkungen: |
Date Completed 29.07.2014 Date Revised 24.07.2014 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1017/S2040174412000748 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM24035351X |
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| 245 | 1 | 0 | |a Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implication of FTO in fetal growth, we measured its placental expression in samples including extremes of abnormal fetal growth, such as after intrauterine growth restriction (IUGR) or macrosomia in both rats and humans. In rats, fetal growth was modulated by maternal nutritional modifications. In humans, placental villi were collected from pathological pregnancies (i.e. with IUGR or fetal macrosomia). Placental FTO mRNA expression was reduced by IUGR but was not significantly affected by macrosomia in either rats or humans. Our data suggest that placental FTO may participate in interactions between the in utero environment and the control of fetal growth under IUGR conditions by modulating epigenetic processes | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Cisse, O |e verfasserin |4 aut | |
| 700 | 1 | |a Gabory, A |e verfasserin |4 aut | |
| 700 | 1 | |a Barbaux, S |e verfasserin |4 aut | |
| 700 | 1 | |a Vaiman, D |e verfasserin |4 aut | |
| 700 | 1 | |a Vambergue, A |e verfasserin |4 aut | |
| 700 | 1 | |a Fajardy, I |e verfasserin |4 aut | |
| 700 | 1 | |a Deloof, S |e verfasserin |4 aut | |
| 700 | 1 | |a Junien, C |e verfasserin |4 aut | |
| 700 | 1 | |a Laborie, C |e verfasserin |4 aut | |
| 700 | 1 | |a Vieau, D |e verfasserin |4 aut | |
| 700 | 1 | |a Lesage, J |e verfasserin |4 aut | |
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