Efficacy of continuous positive airway pressure treatment on 5-year survival in patients with ischaemic stroke and obstructive sleep apnea : a randomized controlled trial
© 2014 European Sleep Research Society..
The main purpose of the present analysis is to assess the influence of introducing early nasal continuous positive airway pressure (nCPAP) treatment on cardiovascular recurrences and mortality in patients with a first-ever ischaemic stroke and moderate-severe obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) ≥20 events h(-1) during a 5-year follow-up. Patients received conventional treatment for stroke and were assigned randomly to the nCPAP group (n = 71) or the control group (n = 69). Cardiovascular events and mortality were registered for all patients. Survival and cardiovascular event-free survival analysis were performed after 5-year follow-up using the Kaplan-Meier test. Patients in the nCPAP group had significantly higher cardiovascular survival than the control group (100 versus 89.9%, log-rank test 5.887; P = 0.015) However, and also despite a positive tendency, there were no significant differences in the cardiovascular event-free survival at 68 months between the nCPAP and control groups (89.5 versus 75.4%, log-rank test 3.565; P = 0.059). Early nCPAP therapy has a positive effect on long-term survival in ischaemic stroke patients and moderate-severe OSA.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Journal of sleep research - 24(2015), 1 vom: 12. Feb., Seite 47-53 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Parra, Olga [VerfasserIn] |
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| Links: |
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| Themen: |
Ischaemic stroke |
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| Anmerkungen: |
Date Completed 17.03.2015 Date Revised 30.03.2022 published: Print-Electronic ErratumIn: J Sleep Res. 2015 Aug;24(4):474. - PMID 26219623 Citation Status MEDLINE |
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| doi: |
10.1111/jsr.12181 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM240219120 |
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| 100 | 1 | |a Parra, Olga |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Efficacy of continuous positive airway pressure treatment on 5-year survival in patients with ischaemic stroke and obstructive sleep apnea |b a randomized controlled trial |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Revised 30.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: J Sleep Res. 2015 Aug;24(4):474. - PMID 26219623 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 European Sleep Research Society. | ||
| 520 | |a The main purpose of the present analysis is to assess the influence of introducing early nasal continuous positive airway pressure (nCPAP) treatment on cardiovascular recurrences and mortality in patients with a first-ever ischaemic stroke and moderate-severe obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) ≥20 events h(-1) during a 5-year follow-up. Patients received conventional treatment for stroke and were assigned randomly to the nCPAP group (n = 71) or the control group (n = 69). Cardiovascular events and mortality were registered for all patients. Survival and cardiovascular event-free survival analysis were performed after 5-year follow-up using the Kaplan-Meier test. Patients in the nCPAP group had significantly higher cardiovascular survival than the control group (100 versus 89.9%, log-rank test 5.887; P = 0.015) However, and also despite a positive tendency, there were no significant differences in the cardiovascular event-free survival at 68 months between the nCPAP and control groups (89.5 versus 75.4%, log-rank test 3.565; P = 0.059). Early nCPAP therapy has a positive effect on long-term survival in ischaemic stroke patients and moderate-severe OSA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a ischaemic stroke | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a nasal continuous positive airway pressure | |
| 700 | 1 | |a Sánchez-Armengol, Ángeles |e verfasserin |4 aut | |
| 700 | 1 | |a Capote, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Bonnin, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Arboix, Adrià |e verfasserin |4 aut | |
| 700 | 1 | |a Campos-Rodríguez, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Ronchel, José |e verfasserin |4 aut | |
| 700 | 1 | |a Durán-Cantolla, Joaquín |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Null, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a de la Peña, Mónica |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez, Maria Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Masa, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Casadon, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso, Maria Luz |e verfasserin |4 aut | |
| 700 | 1 | |a Macarrón, José L |e verfasserin |4 aut | |
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