Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders
Copyright © 2014 Elsevier Ltd. All rights reserved..
The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the proline transporter (PROT), a high affinity Na(+)/Cl(-)-dependent transporter, indicated its potential as a novel therapeutic target for cognition improvement. Herein we report our investigation into a novel class of PROT inhibitors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 24(2014), 16 vom: 15. Aug., Seite 3886-90 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zipp, G Greg [VerfasserIn] |
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| Links: |
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| Themen: |
Acyl piperazine |
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| Anmerkungen: |
Date Completed 06.03.2015 Date Revised 11.08.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2014.06.049 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM240193660 |
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| 245 | 1 | 0 | |a Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders |
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| 500 | |a Date Revised 11.08.2014 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier Ltd. All rights reserved. | ||
| 520 | |a The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the proline transporter (PROT), a high affinity Na(+)/Cl(-)-dependent transporter, indicated its potential as a novel therapeutic target for cognition improvement. Herein we report our investigation into a novel class of PROT inhibitors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acyl piperazine | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a Dimentia | |
| 650 | 4 | |a Inhibitor | |
| 650 | 4 | |a Proline transporter | |
| 650 | 7 | |a Amino Acid Transport Systems, Neutral |2 NLM | |
| 650 | 7 | |a Small Molecule Libraries |2 NLM | |
| 650 | 7 | |a proline transport protein |2 NLM | |
| 700 | 1 | |a Barbosa, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Green, Michael A |e verfasserin |4 aut | |
| 700 | 1 | |a Terranova, Kristen M |e verfasserin |4 aut | |
| 700 | 1 | |a Fink, Cynthia |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xuan-Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Nouraldeen, Amr |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Alan |e verfasserin |4 aut | |
| 700 | 1 | |a Savelieva, Katerina |e verfasserin |4 aut | |
| 700 | 1 | |a Lanthorn, Thomas H |e verfasserin |4 aut | |
| 700 | 1 | |a David Kimball, S |e verfasserin |4 aut | |
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