GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure
Natural estrogens such as 17β-estradiol are endogenous vasodilators and have been implicated in the gender differences of hypertension. These hormones activate estrogen receptors ERα and ERβ, which mediate part of estrogen-dependent vasodilation. In addition, a novel G protein-coupled estrogen-binding receptor termed GPER/GPR30 has been identified that is expressed in the cardiovascular system. Using knock-out animals or drugs selectively targeting GPER/GPR30, a significant role for this receptor as a mediator of acute estrogen-dependent vasodilation involving nitric oxide (NO) and blood pressure-lowering activity has been demonstrated. The accumulating evidence that GPER/GPR30 is responsible for control of vascular tone indicates that this receptor may represent a novel drug target for pharmacologic treatment of hypertension in postmenopausal women and possibly also men.
| Media Type: |
Article |
|---|
| Year of Publication: |
2011 |
|---|---|
| Publication: |
2011 |
| Contained In: |
To Main Record - volume:11 |
|---|---|
| Contained In: |
Immunology, endocrine & metabolic agents in medicinal chemistry - 11(2011), 4 vom: 21., Seite 255-261 |
| Language: |
English |
|---|
| Contributors: |
Meyer, Matthias R [Author] |
|---|
| Keywords: |
Blood Pressure |
|---|
| Notes: |
Date Revised 21.10.2021 published: Print Citation Status PubMed-not-MEDLINE |
|---|
| Supporting institution / Project title: |
|
|---|
| PPN (Catalogue-ID): |
NLM239851455 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM239851455 | ||
| 003 | DE-627 | ||
| 005 | 20231224120845.0 | ||
| 007 | tu | ||
| 008 | 231224s2011 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0799.xml |
| 035 | |a (DE-627)NLM239851455 | ||
| 035 | |a (NLM)24999376 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Meyer, Matthias R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure |
| 264 | 1 | |c 2011 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Natural estrogens such as 17β-estradiol are endogenous vasodilators and have been implicated in the gender differences of hypertension. These hormones activate estrogen receptors ERα and ERβ, which mediate part of estrogen-dependent vasodilation. In addition, a novel G protein-coupled estrogen-binding receptor termed GPER/GPR30 has been identified that is expressed in the cardiovascular system. Using knock-out animals or drugs selectively targeting GPER/GPR30, a significant role for this receptor as a mediator of acute estrogen-dependent vasodilation involving nitric oxide (NO) and blood pressure-lowering activity has been demonstrated. The accumulating evidence that GPER/GPR30 is responsible for control of vascular tone indicates that this receptor may represent a novel drug target for pharmacologic treatment of hypertension in postmenopausal women and possibly also men | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Blood Pressure | |
| 650 | 4 | |a Endothelium | |
| 650 | 4 | |a Hormone Therapy | |
| 650 | 4 | |a Hypertension | |
| 650 | 4 | |a Menopause | |
| 650 | 4 | |a Nitric Oxide | |
| 650 | 4 | |a Vasodilation | |
| 700 | 1 | |a Prossnitz, Eric R |e verfasserin |4 aut | |
| 700 | 1 | |a Barton, Matthias |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Immunology, endocrine & metabolic agents in medicinal chemistry |d 2007 |g 11(2011), 4 vom: 21., Seite 255-261 |w (DE-627)507526643 |w (DE-600)2221719-8 |x 1871-5222 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2011 |g number:4 |g day:21 |g pages:255-261 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 912 | |a GBV_ILN_20 | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2011 |e 4 |b 21 |h 255-261 | ||