GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure
Natural estrogens such as 17β-estradiol are endogenous vasodilators and have been implicated in the gender differences of hypertension. These hormones activate estrogen receptors ERα and ERβ, which mediate part of estrogen-dependent vasodilation. In addition, a novel G protein-coupled estrogen-binding receptor termed GPER/GPR30 has been identified that is expressed in the cardiovascular system. Using knock-out animals or drugs selectively targeting GPER/GPR30, a significant role for this receptor as a mediator of acute estrogen-dependent vasodilation involving nitric oxide (NO) and blood pressure-lowering activity has been demonstrated. The accumulating evidence that GPER/GPR30 is responsible for control of vascular tone indicates that this receptor may represent a novel drug target for pharmacologic treatment of hypertension in postmenopausal women and possibly also men.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2011 |
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| Erschienen: |
2011 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Immunology, endocrine & metabolic agents in medicinal chemistry - 11(2011), 4 vom: 21., Seite 255-261 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Meyer, Matthias R [VerfasserIn] |
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| Themen: |
Blood Pressure |
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| Anmerkungen: |
Date Revised 21.10.2021 published: Print Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM239851455 |
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| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Natural estrogens such as 17β-estradiol are endogenous vasodilators and have been implicated in the gender differences of hypertension. These hormones activate estrogen receptors ERα and ERβ, which mediate part of estrogen-dependent vasodilation. In addition, a novel G protein-coupled estrogen-binding receptor termed GPER/GPR30 has been identified that is expressed in the cardiovascular system. Using knock-out animals or drugs selectively targeting GPER/GPR30, a significant role for this receptor as a mediator of acute estrogen-dependent vasodilation involving nitric oxide (NO) and blood pressure-lowering activity has been demonstrated. The accumulating evidence that GPER/GPR30 is responsible for control of vascular tone indicates that this receptor may represent a novel drug target for pharmacologic treatment of hypertension in postmenopausal women and possibly also men | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Blood Pressure | |
| 650 | 4 | |a Endothelium | |
| 650 | 4 | |a Hormone Therapy | |
| 650 | 4 | |a Hypertension | |
| 650 | 4 | |a Menopause | |
| 650 | 4 | |a Nitric Oxide | |
| 650 | 4 | |a Vasodilation | |
| 700 | 1 | |a Prossnitz, Eric R |e verfasserin |4 aut | |
| 700 | 1 | |a Barton, Matthias |e verfasserin |4 aut | |
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