Accessory proteins of SARS-CoV and other coronaviruses
Copyright © 2014 Elsevier B.V. All rights reserved..
The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses" (see Introduction by Hilgenfeld and Peiris (2013)).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:109 |
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| Enthalten in: |
Antiviral research - 109(2014) vom: 03. Sept., Seite 97-109 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Ding Xiang [VerfasserIn] |
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| Links: |
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| Themen: |
Accessory proteins |
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| Anmerkungen: |
Date Completed 06.04.2015 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.antiviral.2014.06.013 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2014 Elsevier B.V. All rights reserved. | ||
| 520 | |a The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses" (see Introduction by Hilgenfeld and Peiris (2013)) | ||
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| 650 | 4 | |a Accessory proteins | |
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| 700 | 1 | |a Shukla, Aditi |e verfasserin |4 aut | |
| 700 | 1 | |a Hilgenfeld, Rolf |e verfasserin |4 aut | |
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