The Thompson-McFadden Commission and Joseph Goldberger : contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina
© The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
As pellagra reached epidemic proportions in the United States in the early 20th century, 2 teams of investigators assessed its incidence in cotton mill villages in South Carolina. The first, the Thompson-McFadden Commission, concluded that pellagra was likely infectious. The second, a Public Health Service investigation led by Joseph Goldberger, concluded that pellagra was caused by a dietary deficiency. In this paper, we recount the history of the 2 investigations and consider how the differences between the 2 studies' designs, measurements, analyses, and interpretations led to different conclusions. Because the novel dietary assessment strategy was a key feature of the Public Health Service's study design, we incorporated simulated measurement error in a reanalysis of the Public Health Service's data to assess whether this specific difference affected the divergent conclusions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:180 |
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| Enthalten in: |
American journal of epidemiology - 180(2014), 3 vom: 01. Aug., Seite 235-44 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mooney, Stephen J [VerfasserIn] |
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| Links: |
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| Themen: |
Biography |
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| Anmerkungen: |
Date Completed 05.09.2014 Date Revised 04.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1093/aje/kwu134 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 4 | |a The Thompson-McFadden Commission and Joseph Goldberger |b contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina |
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| 520 | |a © The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a As pellagra reached epidemic proportions in the United States in the early 20th century, 2 teams of investigators assessed its incidence in cotton mill villages in South Carolina. The first, the Thompson-McFadden Commission, concluded that pellagra was likely infectious. The second, a Public Health Service investigation led by Joseph Goldberger, concluded that pellagra was caused by a dietary deficiency. In this paper, we recount the history of the 2 investigations and consider how the differences between the 2 studies' designs, measurements, analyses, and interpretations led to different conclusions. Because the novel dietary assessment strategy was a key feature of the Public Health Service's study design, we incorporated simulated measurement error in a reanalysis of the Public Health Service's data to assess whether this specific difference affected the divergent conclusions | ||
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| 650 | 4 | |a Historical Article | |
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| 650 | 4 | |a measurement | |
| 650 | 4 | |a multilevel epidemiology | |
| 650 | 4 | |a nutrition | |
| 700 | 1 | |a Knox, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Morabia, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Goldberger, Joseph |e erwähnter |4 oth | |
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