Enantioselective Pd-catalyzed allylation of acyclic α-fluorinated ketones
Significant synthetic challenges remain for the asymmetric synthesis of tertiary α-fluoro ketones, which are potentially useful molecules for the development of drugs, agrochemicals, and functional materials. Herein, we describe the development of a method for the catalytic enantioselective synthesis of tertiary α-fluoro ketones via the Tsuji-Trost reaction of racemic acyclic α-fluorinated ketones. Enantioenriched acyclic α-cabonyl tertiary fluorides can be produced with the aid of a palladium/phosphinooxazoline catalyst.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:79 |
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| Enthalten in: |
The Journal of organic chemistry - 79(2014), 13 vom: 03. Juli, Seite 6347-53 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Wengui [VerfasserIn] |
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| Links: |
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| Themen: |
5TWQ1V240M |
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| Anmerkungen: |
Date Completed 09.12.2014 Date Revised 03.07.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/jo500923u |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM23905380X |
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| 245 | 1 | 0 | |a Enantioselective Pd-catalyzed allylation of acyclic α-fluorinated ketones |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Significant synthetic challenges remain for the asymmetric synthesis of tertiary α-fluoro ketones, which are potentially useful molecules for the development of drugs, agrochemicals, and functional materials. Herein, we describe the development of a method for the catalytic enantioselective synthesis of tertiary α-fluoro ketones via the Tsuji-Trost reaction of racemic acyclic α-fluorinated ketones. Enantioenriched acyclic α-cabonyl tertiary fluorides can be produced with the aid of a palladium/phosphinooxazoline catalyst | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Wan, Xiao-Long |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Qing-Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yong |e verfasserin |4 aut | |
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