Factors that predict a positive response on gonadotropin-releasing hormone stimulation test for diagnosing central precocious puberty in girls

PURPOSE: The rapid increase in the incidence of precocious puberty in Korea has clinical and social significance. Gonadotropin-releasing hormone (GnRH) stimulation test is required to diagnose central precocious puberty (CPP), however this test is expensive and time-consuming. This study aimed to identify factors that can predict a positive response to the GnRH stimulation test.

METHODS: Clinical and laboratory parameters, including basal serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol (E2), were measured in 540 girls with clinical signs of CPP.

RESULTS: Two hundred twenty-nine of 540 girls with suspected CPP had a peak serum LH level higher than 5 IU/L (the CPP group). The CPP group had advanced bone age (P<0.001), accelerated yearly growth rate (P<0.001), increased basal levels of LH (P=0.02), FSH (P<0.001), E2 (P=0.001), and insulin-like growth factor-I levels (P<0.001) compared to the non-CPP group. In contrast, body weight (P<0.001) and body mass index (P<0.001) were lower in the CPP group. Although basal LH was significantly elevated in the CPP group compared to the non-CPP group, there was considerable overlap between the 2 groups. Cutoff values of basal LH (0.22 IU/L) detected CPP with 87.8% sensitivity and 20.9% specificity.

CONCLUSION: No single parameter can predict a positive response on the GnRH stimulation test with both high sensitivity and specificity. Therefore, multiple factors should be considered in evaluation of sexual precocity when deciding the timing of the GnRH stimulation test.

Medienart:

E-Artikel

Erscheinungsjahr:

2013

Erschienen:

2013

Enthalten in:

Zur Gesamtaufnahme - volume:18

Enthalten in:

Annals of pediatric endocrinology & metabolism - 18(2013), 4 vom: 01. Dez., Seite 202-7

Sprache:

Englisch

Beteiligte Personen:

Suh, Junghwan [VerfasserIn]
Choi, Myung Hyun [VerfasserIn]
Kwon, Ah Reum [VerfasserIn]
Kim, Ye Jin [VerfasserIn]
Jeong, Jin Woo [VerfasserIn]
Ahn, Jung Min [VerfasserIn]
Chae, Hyun Wook [VerfasserIn]
Kim, Duk Hee [VerfasserIn]
Kim, Ho-Seong [VerfasserIn]

Links:

Volltext

Themen:

Diagnosis
Female
Forecasting
Gonadotropin-releasing hormone
Journal Article
Precocious puberty

Anmerkungen:

Date Completed 06.06.2014

Date Revised 21.10.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.6065/apem.2013.18.4.202

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM238949648