Variable change in renal function by hypertonic saline
AIM: To investigate the effects of hypertonic saline in the neurocritical care population.
METHODS: We retrospectively reviewed our hospital's use of hypertonic saline (HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change (Cr), and HS formulation (3% NaCl, 3% NaCl/sodium acetate mix, and 23.4% NaCl) to patients receiving normal saline or lactated ringers. The patients (n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data.
RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation II scores and Glasgow Coma Scale scores occurred between different saline formulations. No significant correlation of Cl(-) or Na(+) with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury (TBI) patients demonstrated moderate correlation between Na(+) and Cr of 0.45. Stroke patients demonstrated weak correlations between Na(+) and Cr, and Cl(-) and Cr (0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl(-) and Cr at 0.29.
CONCLUSION: Cr directly correlates with Na(+) or Cl(-) in stroke, Na(+) in TBI, and Cl(-) in other populations. Prospective comparison of HS and renal function is needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
|---|---|
| Enthalten in: |
World journal of critical care medicine - 3(2014), 2 vom: 04. Mai, Seite 61-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Corry, Jesse J [VerfasserIn] |
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| Links: |
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| Themen: |
Acute kidney injury |
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| Anmerkungen: |
Date Completed 03.06.2014 Date Revised 21.10.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.5492/wjccm.v3.i2.61 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM238827208 |
|---|
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| 100 | 1 | |a Corry, Jesse J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Variable change in renal function by hypertonic saline |
| 264 | 1 | |c 2014 | |
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| 500 | |a Date Completed 03.06.2014 | ||
| 500 | |a Date Revised 21.10.2021 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a AIM: To investigate the effects of hypertonic saline in the neurocritical care population | ||
| 520 | |a METHODS: We retrospectively reviewed our hospital's use of hypertonic saline (HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change (Cr), and HS formulation (3% NaCl, 3% NaCl/sodium acetate mix, and 23.4% NaCl) to patients receiving normal saline or lactated ringers. The patients (n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data | ||
| 520 | |a RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation II scores and Glasgow Coma Scale scores occurred between different saline formulations. No significant correlation of Cl(-) or Na(+) with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury (TBI) patients demonstrated moderate correlation between Na(+) and Cr of 0.45. Stroke patients demonstrated weak correlations between Na(+) and Cr, and Cl(-) and Cr (0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl(-) and Cr at 0.29 | ||
| 520 | |a CONCLUSION: Cr directly correlates with Na(+) or Cl(-) in stroke, Na(+) in TBI, and Cl(-) in other populations. Prospective comparison of HS and renal function is needed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute kidney injury | |
| 650 | 4 | |a Cerebral edema | |
| 650 | 4 | |a Critical care | |
| 650 | 4 | |a Hypertonic saline solution | |
| 650 | 4 | |a Sodium chloride | |
| 700 | 1 | |a Varelas, Panayiotis |e verfasserin |4 aut | |
| 700 | 1 | |a Abdelhak, Tamer |e verfasserin |4 aut | |
| 700 | 1 | |a Morris, Stacey |e verfasserin |4 aut | |
| 700 | 1 | |a Hawley, Marlisa |e verfasserin |4 aut | |
| 700 | 1 | |a Hawkins, Allison |e verfasserin |4 aut | |
| 700 | 1 | |a Jankowski, Michelle |e verfasserin |4 aut | |
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