Crinane alkaloids of the amaryllidaceae with cytotoxic effects in human cervical adenocarcinoma (HeLa) cells
The family Amaryllidaceae has a long history of usage in the traditional medicinal practices of the indigenous peoples of South Africa, with three of its species known to be used for cancer treatment. Furthermore, the Amaryllidaceae is widely recognized for its unique alkaloid constituents, several of which exhibit potent and selective cytotoxic activities. In this study, several crinane alkaloids derived from local Amaryllidaceae species were examined for cytotoxic effects against the human cervical adenocarcinoma cell line, of which distichamine was the most potent (IC50 2.2 microM).
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Natural product communications - 9(2014), 4 vom: 24. Apr., Seite 461-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nair, Jerald J [VerfasserIn] |
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| Themen: |
Amaryllidaceae Alkaloids |
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| Anmerkungen: |
Date Completed 26.06.2014 Date Revised 29.05.2014 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM238625222 |
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| 245 | 1 | 0 | |a Crinane alkaloids of the amaryllidaceae with cytotoxic effects in human cervical adenocarcinoma (HeLa) cells |
| 264 | 1 | |c 2014 | |
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| 500 | |a Date Completed 26.06.2014 | ||
| 500 | |a Date Revised 29.05.2014 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The family Amaryllidaceae has a long history of usage in the traditional medicinal practices of the indigenous peoples of South Africa, with three of its species known to be used for cancer treatment. Furthermore, the Amaryllidaceae is widely recognized for its unique alkaloid constituents, several of which exhibit potent and selective cytotoxic activities. In this study, several crinane alkaloids derived from local Amaryllidaceae species were examined for cytotoxic effects against the human cervical adenocarcinoma cell line, of which distichamine was the most potent (IC50 2.2 microM) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Amaryllidaceae Alkaloids |2 NLM | |
| 650 | 7 | |a Cytotoxins |2 NLM | |
| 700 | 1 | |a Rárová, Lucie |e verfasserin |4 aut | |
| 700 | 1 | |a Strnad, Miroslav |e verfasserin |4 aut | |
| 700 | 1 | |a Bastida, Jaume |e verfasserin |4 aut | |
| 700 | 1 | |a Cheesman, Lee |e verfasserin |4 aut | |
| 700 | 1 | |a van Staden, Johannes |e verfasserin |4 aut | |
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