Changes of serum adhesion molecules and cytokines in post-ERCP pancreatitis : adhesion molecules and cytokines in acute pancreatitis
Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved..
OBJECTIVES: To assess the early changes of soluble IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF-α, TNF-β, IL-17A, IL-22, soluble (s) P-Selectin, sE-Selectin and sICAM-1 in post-ERCP pancreatitis (PEP).
METHODS: Single center, prospective study of 318 ERCP procedures. Serum samples were acquired from all patients prior to ERCP, 6 hours and 24 hours after the procedure. For every PEP case, another patient was chosen as a control, matched for gender, age and time period in which ERCP took place.
RESULTS: Totally, 28 cases and 28 controls were studied. Except for significantly higher IL-1b levels in cases at baseline, no significant differences were observed between cases and controls after Bonferroni corrections. An increase in IL-6 was noted between baseline and 6 h in cases alone (p=0.016). There was a significant fall in sP-selectin levels at 6 and 24 hours compared to baseline in all patients (corrected p=0.008 and 0.016 for cases and 0.016 and 0.048 for controls respectively). An increase of sE-selectin in cases was observed between 6 and 24 hours post-ERCP (corrected p=0.03).
CONCLUSIONS: Soluble forms of cytokines and adhesion molecules studied seem not to play a major role in PEP.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
Clinical biochemistry - 47(2014), 13-14 vom: 21. Sept., Seite 1245-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sigounas, Dimitrios E [VerfasserIn] |
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| Links: |
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| Themen: |
Adhesion molecules |
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| Anmerkungen: |
Date Completed 12.05.2015 Date Revised 25.08.2014 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clinbiochem.2014.05.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Sigounas, Dimitrios E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Changes of serum adhesion molecules and cytokines in post-ERCP pancreatitis |b adhesion molecules and cytokines in acute pancreatitis |
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| 500 | |a Date Revised 25.08.2014 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: To assess the early changes of soluble IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF-α, TNF-β, IL-17A, IL-22, soluble (s) P-Selectin, sE-Selectin and sICAM-1 in post-ERCP pancreatitis (PEP) | ||
| 520 | |a METHODS: Single center, prospective study of 318 ERCP procedures. Serum samples were acquired from all patients prior to ERCP, 6 hours and 24 hours after the procedure. For every PEP case, another patient was chosen as a control, matched for gender, age and time period in which ERCP took place | ||
| 520 | |a RESULTS: Totally, 28 cases and 28 controls were studied. Except for significantly higher IL-1b levels in cases at baseline, no significant differences were observed between cases and controls after Bonferroni corrections. An increase in IL-6 was noted between baseline and 6 h in cases alone (p=0.016). There was a significant fall in sP-selectin levels at 6 and 24 hours compared to baseline in all patients (corrected p=0.008 and 0.016 for cases and 0.016 and 0.048 for controls respectively). An increase of sE-selectin in cases was observed between 6 and 24 hours post-ERCP (corrected p=0.03) | ||
| 520 | |a CONCLUSIONS: Soluble forms of cytokines and adhesion molecules studied seem not to play a major role in PEP | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adhesion molecules | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a ELISA | |
| 650 | 4 | |a ERCP | |
| 650 | 4 | |a Flow cytometry | |
| 650 | 4 | |a Pancreatitis | |
| 650 | 7 | |a Cell Adhesion Molecules |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 700 | 1 | |a Christodoulou, Dimitrios K |e verfasserin |4 aut | |
| 700 | 1 | |a Karamoutsios, Achilleas |e verfasserin |4 aut | |
| 700 | 1 | |a Tatsioni, Athina |e verfasserin |4 aut | |
| 700 | 1 | |a Dova, Lefkothea |e verfasserin |4 aut | |
| 700 | 1 | |a Vartholomatos, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Kolaitis, Nikolaos |e verfasserin |4 aut | |
| 700 | 1 | |a Katsanos, Konstantinos H |e verfasserin |4 aut | |
| 700 | 1 | |a Zervou, Eleftheria |e verfasserin |4 aut | |
| 700 | 1 | |a Ioannidis, John P A |e verfasserin |4 aut | |
| 700 | 1 | |a Tsianos, Epameinondas V |e verfasserin |4 aut | |
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