Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis
© 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd..
AIM: Nonspecific chronic synovitis of the knee joint was reported by Pollard in 1962 and its pathogenesis is considered to be a physiological reaction to intra-articular disease. In this study, we evaluated the pathological findings of the synovium of early osteoarthritis (OA)-affected knee joints with hydrarthrosis in comparison to typical OA.
METHODS: Synovial tissues were harvested from early OA knee joints with hydrarthrosis graded 0-2 according to the Kellgren and Lawrence classification and examined by histopathology.
RESULTS: The synovial tissues showed proliferation of fibroblast-like synoviocytes (FLS) as if in rheumatoid arthritis (RA), and were immunohistochemically positive for matrix metalloproteinase 3, tumor necrosis factor α and interleukin 6.
CONCLUSIONS: The histology of RA is characterized by marked proliferation of FLS. In this study, the synovial tissues of early OA with hydrarthrosis showed moderate FLS proliferation. They also expressed the cytokines that are detected in the synovial tissues of RA. We suggest long-term follow-up is needed because early OA with hydrarthrosis might progress to overt RA.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
|---|---|
| Enthalten in: |
International journal of rheumatic diseases - 19(2016), 5 vom: 02. Mai, Seite 465-9 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kurose, Rie [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 14.07.2017 Date Revised 16.11.2017 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/1756-185X.12404 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM238336840 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM238336840 | ||
| 003 | DE-627 | ||
| 005 | 20231224113554.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/1756-185X.12404 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0794.xml |
| 035 | |a (DE-627)NLM238336840 | ||
| 035 | |a (NLM)24837400 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kurose, Rie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.07.2017 | ||
| 500 | |a Date Revised 16.11.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd. | ||
| 520 | |a AIM: Nonspecific chronic synovitis of the knee joint was reported by Pollard in 1962 and its pathogenesis is considered to be a physiological reaction to intra-articular disease. In this study, we evaluated the pathological findings of the synovium of early osteoarthritis (OA)-affected knee joints with hydrarthrosis in comparison to typical OA | ||
| 520 | |a METHODS: Synovial tissues were harvested from early OA knee joints with hydrarthrosis graded 0-2 according to the Kellgren and Lawrence classification and examined by histopathology | ||
| 520 | |a RESULTS: The synovial tissues showed proliferation of fibroblast-like synoviocytes (FLS) as if in rheumatoid arthritis (RA), and were immunohistochemically positive for matrix metalloproteinase 3, tumor necrosis factor α and interleukin 6 | ||
| 520 | |a CONCLUSIONS: The histology of RA is characterized by marked proliferation of FLS. In this study, the synovial tissues of early OA with hydrarthrosis showed moderate FLS proliferation. They also expressed the cytokines that are detected in the synovial tissues of RA. We suggest long-term follow-up is needed because early OA with hydrarthrosis might progress to overt RA | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a fibroblast-like synoviocytes | |
| 650 | 4 | |a knee | |
| 650 | 4 | |a osteoarthritis | |
| 650 | 4 | |a pathology | |
| 650 | 4 | |a rheumatoid arthritis | |
| 650 | 4 | |a synovium | |
| 650 | 7 | |a IL6 protein, human |2 NLM | |
| 650 | 7 | |a Interleukin-6 |2 NLM | |
| 650 | 7 | |a Tumor Necrosis Factor-alpha |2 NLM | |
| 650 | 7 | |a MMP3 protein, human |2 NLM | |
| 650 | 7 | |a EC 3.4.24.17 |2 NLM | |
| 650 | 7 | |a Matrix Metalloproteinase 3 |2 NLM | |
| 650 | 7 | |a EC 3.4.24.17 |2 NLM | |
| 700 | 1 | |a Kakizaki, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Akimoto, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yagihashi, Norito |e verfasserin |4 aut | |
| 700 | 1 | |a Sawai, Takashi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of rheumatic diseases |d 2009 |g 19(2016), 5 vom: 02. Mai, Seite 465-9 |w (DE-627)NLM197180566 |x 1756-185X |7 nnns |
| 773 | 1 | 8 | |g volume:19 |g year:2016 |g number:5 |g day:02 |g month:05 |g pages:465-9 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/1756-185X.12404 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 19 |j 2016 |e 5 |b 02 |c 05 |h 465-9 | ||