A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
Copyright © 2014 Elsevier Inc. All rights reserved..
The close vicinity of cancer cells undergoing epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) at the invasive front of tumors suggests that these two cell type may mutually interact. We show that mesenchymal-like breast cancer cells activate macrophages to a TAM-like phenotype by GM-CSF. Reciprocally, CCL18 from TAMs induces cancer cell EMT, forming a positive feedback loop, in coculture systems and humanized mice. Inhibition of GM-CSF or CCL18 breaks this loop and reduces cancer metastasis. High GM-CSF expression in breast cancer samples is associated with more CCL18(+) macrophages, cancer cell EMT, enhanced metastasis, and reduced patient survival. These findings suggest that a positive feedback loop between GM-CSF and CCL18 is important in breast cancer metastasis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Cancer cell - 25(2014), 5 vom: 12. Mai, Seite 605-20 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Su, Shicheng [VerfasserIn] |
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| Links: |
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| Themen: |
83869-56-1 |
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| Anmerkungen: |
Date Completed 15.07.2014 Date Revised 08.04.2022 published: Print GEO: GSE51938 Citation Status MEDLINE |
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| doi: |
10.1016/j.ccr.2014.03.021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM238208168 |
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| 500 | |a published: Print | ||
| 500 | |a GEO: GSE51938 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2014 Elsevier Inc. All rights reserved. | ||
| 520 | |a The close vicinity of cancer cells undergoing epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) at the invasive front of tumors suggests that these two cell type may mutually interact. We show that mesenchymal-like breast cancer cells activate macrophages to a TAM-like phenotype by GM-CSF. Reciprocally, CCL18 from TAMs induces cancer cell EMT, forming a positive feedback loop, in coculture systems and humanized mice. Inhibition of GM-CSF or CCL18 breaks this loop and reduces cancer metastasis. High GM-CSF expression in breast cancer samples is associated with more CCL18(+) macrophages, cancer cell EMT, enhanced metastasis, and reduced patient survival. These findings suggest that a positive feedback loop between GM-CSF and CCL18 is important in breast cancer metastasis | ||
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| 700 | 1 | |a Liu, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jingqi |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jianing |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a He, Chonghua |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Di |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Xiuying |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Haiyan |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Herui |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Fengxi |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Erwei |e verfasserin |4 aut | |
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